Dual-emissive Iridium(III) Complexes as Phosphorescent Probes with Orthogonal Responses to Analyte Binding and Oxygen Quenching

Rongji Zhu; Peiling Dai; Jun Yang; Jie Zhou; Jin Zhang; Kenneth Yin Zhang; Yonghua Li; Shujuan Liu; Kenneth Kam-Wing Lo; Qiang Zhao

doi:10.1002/anie.202309178

Author(s)

Rongji Zhu
Peiling Dai
Jun Yang
Jie Zhou
Jin Zhang
Kenneth Yin Zhang
Yonghua Li
Shujuan Liu
Qiang Zhao

Related Research Unit(s)

Department of Chemistry

Detail(s)

Original language	English
Article number	e202309178
Journal / Publication	Angewandte Chemie - International Edition
Volume	62
Issue number	37
Online published	28 Jul 2023
Publication status	Published - 11 Sept 2023

Link(s)

DOI	DOI https://doi.org/10.1002/anie.202309178 Final Published version
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Attachment(s)	Documents 163525839.pdf Post-print, 1.26 MB, PDF Publisher's Copyright Statement This is the peer reviewed version of the following article: Zhu, R., Dai, P., Yang, J., & Zhou, J. et al. (2023). Dual-emissive Iridium(III) Complexes as Phosphorescent Probes with Orthogonal Responses to Analyte Binding and Oxygen Quenching. Angewandte Chemie - International Edition, 62(37), Article e202309178, which has been published in final form at https://doi.org/10.1002/anie.202309178. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85166566674&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c5523b51-7afb-46f6-a961-ddae7199641e).html

Abstract

Phosphorescent probes often show sensitive response toward analytes at a specific wavelength. However, oxygen quenching usually occurs at the same wavelength and thus hinders the accurate detection of analytes. In this study, we have developed dual-emissive iridium(III) complexes that exhibit phosphorescence responses to copper(II) ions at a wavelength distinct from that where oxygen quenching occurs. The complexes displayed colorimetric phosphorescence response in aqueous solutions under different copper(II) and oxygen conditions. In cellular imaging, variation in oxygen concentration over a large range from 5 % to 80 % can modulate the intensity and lifetime of green phosphorescence without affecting the response of red phosphorescence toward intracellular copper(II) ions. © 2023 Wiley-VCH GmbH.