Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Soon-Jung Park
  • Ri Youn Kim
  • Bong-Woo Park
  • Seong Woo Choi
  • Jae-Hyun Park
  • Jong Jin Choi
  • Seok-Won Kim
  • Jinah Jang
  • Dong-Woo Cho
  • Hyung-Min Chung
  • Sung-Hwan Moon
  • Hun-Jun Park

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Detail(s)

Original languageEnglish
Article number3123
Journal / PublicationNature Communications
Volume10
Issue number1
Online published16 Jul 2019
Publication statusPublished - 2019

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Abstract

Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target both so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits the advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and human mesenchymal stem cell-loaded patch (hMSC-PA) to amplify cardiac repair in a rat MI model. Epicardially implanted hMSC-PA provide a complimentary microenvironment which enhances vascular regeneration through prolonged secretion of paracrine factors, but more importantly it significantly improves the retention and engraftment of intramyocardially injected hiPSC-CMs which ultimately restore the cardiac function. Notably, the majority of injected hiPSC-CMs display adult CMs like morphology suggesting that the secretomic milieu of hMSC-PA constitutes pleiotropic effects in vivo. We provide compelling evidence that this dual approach can be a promising means to enhance cardiac repair on MI hearts.

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Citation Format(s)

Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. / Park, Soon-Jung; Kim, Ri Youn; Park, Bong-Woo; Lee, Sunghun; Choi, Seong Woo; Park, Jae-Hyun; Choi, Jong Jin; Kim, Seok-Won; Jang, Jinah; Cho, Dong-Woo; Chung, Hyung-Min; Moon, Sung-Hwan; Ban, Kiwon; Park, Hun-Jun.

In: Nature Communications, Vol. 10, No. 1, 3123, 2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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