Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5: Yb/Er

Songjun Zeng; Ming-Kiu Tsang; Chi-Fai Chan; Ka-Leung Wong; Bin Fei; Jianhua Hao

doi:10.1039/c2nr31294h

Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF ₅: Yb/Er

Songjun Zeng
, Ming-Kiu Tsang
, Chi-Fai Chan
, Ka-Leung Wong
, Bin Fei
, Jianhua Hao

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

102 Citations (Scopus)

Abstract

A new type of BaGdF ₅:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF ₅:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF ₅:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF ₅:Yb/Er NPs. Moreover, these BaGdF ₅ NPs exhibit excellent intrinsic paramagnetic properties and enhanced T ₁-weighted MRI images with increased concentrations of BaGdF ₅ NPs. Therefore, these results suggest that the amine-functionalized BaGdF ₅ NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI. © 2012 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	5118-5124
Journal	Nanoscale
Volume	4
Issue number	16
DOIs	https://doi.org/10.1039/c2nr31294h
Publication status	Published - 21 Aug 2012
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was supported by the Innovation and Technology Support Programme of Hong Kong (Project no. ITS/008/10), the National Natural Science Foundation of China (no. 51102202) and Specialized Research Fund for the Doctoral Program of Higher Education of China (no. 20114301120006). We thank Prof. Fuyou Li in Fudan University for his assistance with MRI measurements and helpful discussions.

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title = "Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5: Yb/Er",

abstract = "A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI. {\textcopyright} 2012 The Royal Society of Chemistry.",

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TY - JOUR

T1 - Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5

T2 - Yb/Er

AU - Zeng, Songjun

AU - Tsang, Ming-Kiu

AU - Chan, Chi-Fai

AU - Wong, Ka-Leung

AU - Fei, Bin

AU - Hao, Jianhua

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2012/8/21

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N2 - A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI. © 2012 The Royal Society of Chemistry.

AB - A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI. © 2012 The Royal Society of Chemistry.

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