Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

Raymond Wai-Yin Sun; Miro Fei-Yeung Ng; Ella Lai-Ming Wong; Jingfei Zhang; Stephen Sin-Yin Chui; Lam Shek; Tai-Chu Lau; Chi-Ming Che

doi:10.1039/b912236b

Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

Raymond Wai-Yin Sun
, Miro Fei-Yeung Ng
, Ella Lai-Ming Wong
, Jingfei Zhang
, Stephen Sin-Yin Chui
, Lam Shek
, Tai-Chu Lau
, Chi-Ming Che

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

34 Citations (Scopus)

Abstract

An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)₄X₂] ⁺ exhibit dual anti-angiogenic and cytotoxic properties. © The Royal Society of Chemistry 2009.

Original language	English
Pages (from-to)	10712-10716
Journal	Dalton Transactions
Issue number	48
DOIs	https://doi.org/10.1039/b912236b
Publication status	Published - 2009

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SDG 3 Good Health and Well-being

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@article{8885e0714b664cc3821eb1450af46209,

title = "Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands",

abstract = "An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60\%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2] + exhibit dual anti-angiogenic and cytotoxic properties. {\textcopyright} The Royal Society of Chemistry 2009.",

author = "Sun, \{Raymond Wai-Yin\} and Ng, \{Miro Fei-Yeung\} and Wong, \{Ella Lai-Ming\} and Jingfei Zhang and Chui, \{Stephen Sin-Yin\} and Lam Shek and Tai-Chu Lau and Chi-Ming Che",

year = "2009",

doi = "10.1039/b912236b",

language = "English",

pages = "10712--10716",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "48",

}

TY - JOUR

T1 - Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

AU - Sun, Raymond Wai-Yin

AU - Ng, Miro Fei-Yeung

AU - Wong, Ella Lai-Ming

AU - Zhang, Jingfei

AU - Chui, Stephen Sin-Yin

AU - Shek, Lam

AU - Lau, Tai-Chu

AU - Che, Chi-Ming

PY - 2009

Y1 - 2009

N2 - An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2] + exhibit dual anti-angiogenic and cytotoxic properties. © The Royal Society of Chemistry 2009.

AB - An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2] + exhibit dual anti-angiogenic and cytotoxic properties. © The Royal Society of Chemistry 2009.

UR - https://www.scopus.com/pages/publications/71549116074

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-71549116074&origin=recordpage

U2 - 10.1039/b912236b

DO - 10.1039/b912236b

M3 - RGC 21 - Publication in refereed journal

C2 - 20023898

SN - 1477-9226

SP - 10712

EP - 10716

JO - Dalton Transactions

JF - Dalton Transactions

IS - 48

ER -

Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

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