Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Lei Jiang
  • Yangchao Chen
  • Chu-yan Chan
  • Xin Wang
  • Lin Lin
  • Marie C.M. Lin
  • David T. Yew
  • Joseph J.Y. Sung
  • Ji-Cheng Li
  • Hsiang-fu Kung

Detail(s)

Original languageEnglish
Pages (from-to)101-108
Journal / PublicationCancer Letters
Volume274
Issue number1
Publication statusPublished - 8 Feb 2009
Externally publishedYes

Abstract

Transforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.

Research Area(s)

  • Apoptosis, Chemosensitivity, Pancreatic cancer, Stathmin, TIEG1

Citation Format(s)

Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells. / Jiang, Lei; Chen, Yangchao; Chan, Chu-yan; Wang, Xin; Lin, Lin; He, Ming-liang; Lin, Marie C.M.; Yew, David T.; Sung, Joseph J.Y.; Li, Ji-Cheng; Kung, Hsiang-fu.

In: Cancer Letters, Vol. 274, No. 1, 08.02.2009, p. 101-108.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review