Double-sided plasmonic metasurface for simultaneous biomolecular separation and SERS detection

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Shuangbao Lyu
  • Yongliang Zhang
  • Guanghua Du
  • Cuixia Di
  • Huijun Yao
  • Yulong Fan
  • Jinglai Duan

Detail(s)

Original languageEnglish
Article number121801
Journal / PublicationSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume285
Online published12 Sep 2022
Publication statusPublished - 15 Jan 2023

Abstract

Porous membrane-based nanofiltration separation of small biomolecules is a widely used biotechnology for which size-based selectivity is a critical parameter of technological relevance. Efficient determination of size selectivity calls for an advanced detection method capable of performing sensitive, rapid, and on-membrane examination. Surface-enhanced Raman spectroscopy (SERS) is such a detection method that has been widely recognized as an ultrasensitive technique for trace-level detection with sensitivity down to the single-molecule level. In this work, we for the first time develop a double-sided hierarchical porous membrane-like plasmonic metasurface to realize high-selectivity bimolecular separation and simultaneous ultrasensitive SERS detection. This highly flexible device, consisting of subwavelength nanocone pairs surrounded by randomly orientated sub-5 nm nanogrooves, was prepared by combining customized “top-down” fabrication of conical nanopores in an ion-track registered polycarbonate membrane and self-assembly of nanogrooves on the membrane surface through physical vapor deposition. The unique tip-to-tip oriented conical nanopores in the device enables excellent size-based molecular selectivity; the hierarchical groove-pore structure supports a peculiar cascaded electromagnetic near-field enhancement mechanism, endowing the device with SERS-based molecular detection of ultrahigh sensitivity, uniformity, repeatability, and polarization independence. With such dual structural merits and performance enhancement, we demonstrate effective nanofiltration separation of small-sized adenine from big-sized ss-DNA and synergistic SERS determination of their species. We experimentally demonstrate an ultrasensitive detection of 4-mercaptopyridine down to 10 pM. Together with its unparalleled mechanical flexibility, this double-side-responsive plasmonic metasurface membrane can find great potential in real-world molecular filtration and detection under extremely complex working conditions.

Research Area(s)

  • Biomolecular nanofiltration membrane, Double-side responsivity, Metasurface, Plasmonics, Surface-enhanced Raman spectroscopy

Citation Format(s)

Double-sided plasmonic metasurface for simultaneous biomolecular separation and SERS detection. / Lyu, Shuangbao; Zhang, Yongliang; Du, Guanghua et al.

In: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 285, 121801, 15.01.2023.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review