Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jeffery Ho
  • Rudin Z. W. Dai
  • Thomas N. Y. Kwong
  • Xiansong Wang
  • Lin Zhang
  • And 15 others
  • Margaret Ip
  • Raphael Chan
  • Peter M. K. Hawkey
  • Kelvin L. Y. Lam
  • Martin C. S. Wong
  • Gary Tse
  • Matthew T. V. Chan
  • Francis K. L. Chan
  • Jun Yu
  • Siew C. Ng
  • Nelson Lee
  • Justin C. Y. Wu
  • Joseph J. Y. Sung
  • William K. K. Wu
  • Sunny H. Wong

Detail(s)

Original languageEnglish
Pages (from-to)1671-1679
Number of pages9
Journal / PublicationEmerging Infectious Diseases
Volume23
Issue number10
Publication statusPublished - Oct 2017
Externally publishedYes

Link(s)

Abstract

Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population. 

Research Area(s)

  • RIBOTYPE 002, EPIDEMIOLOGY, RISK, ANTIBIOTICS, UPDATE, MEAT

Citation Format(s)

Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014. / Ho, Jeffery; Dai, Rudin Z. W.; Kwong, Thomas N. Y.; Wang, Xiansong; Zhang, Lin; Ip, Margaret; Chan, Raphael; Hawkey, Peter M. K.; Lam, Kelvin L. Y.; Wong, Martin C. S.; Tse, Gary; Chan, Matthew T. V.; Chan, Francis K. L.; Yu, Jun; Ng, Siew C.; Lee, Nelson; Wu, Justin C. Y.; Sung, Joseph J. Y.; Wu, William K. K.; Wong, Sunny H.

In: Emerging Infectious Diseases, Vol. 23, No. 10, 10.2017, p. 1671-1679.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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