Discriminating Alzheimer's patients from cognitively normal older adults based on hippocampal volumes-voxel-based morphometry with DARTEL and standard registration versus manual volumetry

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)peer-review

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Author(s)

  • Henry Ka-Fung Mak
  • Zhipeng Zhang
  • Linda Zhang
  • Queenie Chan
  • Leung-Wing Chu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Title of host publicationHandbook of Imaging the Alzheimer Brain
Pages729-737
Volume2
Publication statusPublished - 2011

Publication series

NameAdvances in Alzheimer's Disease
Volume2
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735

Abstract

Hippocampal atrophy on Magnetic Resonance Imaging (MRI) has been increasingly used as a supportive feature for the diagnosis of Alzheimer's patients. We attempt to compare voxel-based morphometry (VBM) with DARTEL and standard registration versus manual hippocampal volumetry in discriminating Alzheimer's disease (AD) patients from cognitively normal older adults. Participants were 20 cognitively normal elderly subjects and 19 AD patients who met the criteria of probable AD according to NINCDS-ADRDA. High resolution T1-weighted (T1W) 3D volumetric Fast Field Echo sequence was obtained using 3.0-Tesla scanner. Bilateral manual hippocampal volumetry (ANALYZE 7.0 software) and VBM hippocampal region-of-interests (using hippocampal masks MARINA) were generated with DARTEL and standard registration (Statistical Parametric Mapping SPM5 software). Normalization with total intracranial volumes was employed for both methods. All normalized hippocampal measurements showed significant reduction (20-30%; p <0.001) in AD compared to controls. Logistic regression analysis also showed significant effects (odds ratios ranged from 88.2% to 94.0%) of all normalized measurements in predicting AD incidence after adjusting for age, gender, and education. The overall prediction accuracies of manual RH and LH volumes, standard RH-ROI and LH-ROI VBM, DARTEL RH-ROI and LH-ROI VBM were 87.2%, 84.6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults. © 2011 The authors and IOS Press. All rights reserved.

Research Area(s)

  • Alzheimer's disease, ANALYZE 7.0 software, cognitively normal older adults, Magnetic Resonance Imaging, Manual hippocampal volumetry, SPM5 software with DARTEL registration, voxel-based morphometry

Citation Format(s)

Discriminating Alzheimer's patients from cognitively normal older adults based on hippocampal volumes-voxel-based morphometry with DARTEL and standard registration versus manual volumetry. / Mak, Henry Ka-Fung; Zhang, Zhipeng; Yau, Kelvin Kai-Wing; Zhang, Linda; Chan, Queenie; Chu, Leung-Wing.

Handbook of Imaging the Alzheimer Brain. Vol. 2 2011. p. 729-737 (Advances in Alzheimer's Disease; Vol. 2).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)peer-review