Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Osamu Irie
  • Takatoshi Kosaka
  • Takeru Ehara
  • Fumiaki Yokokawa
  • Takanori Kanazawa
  • Astuko Iwasaki
  • Junichi Sakaki
  • Naoki Teno
  • Yuko Hitomi
  • Genji Iwasaki
  • Hiroaki Fukaya
  • Kazuhiko Nonomura
  • Keiko Tanabe
  • Shinichi Koizumi
  • Noriko Uchiyama
  • Stuart J. Bevan
  • Marzia Malcangio
  • Clive Gentry
  • Alyson J. Fox
  • Mohammed Yaqoob
  • Andrew J. Culshaw
  • Allan Hallett

Detail(s)

Original languageEnglish
Pages (from-to)5502-5505
Journal / PublicationJournal of Medicinal Chemistry
Volume51
Issue number18
Publication statusPublished - 25 Sep 2008
Externally publishedYes

Abstract

Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the efficacy of selective cathepsin S inhibitors as antihyperalgesics in a model of neuropathic pain in rats after oral administration. © 2008 American Chemical Society.

Citation Format(s)

Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. / Irie, Osamu; Kosaka, Takatoshi; Ehara, Takeru; Yokokawa, Fumiaki; Kanazawa, Takanori; Hirao, Hajime; Iwasaki, Astuko; Sakaki, Junichi; Teno, Naoki; Hitomi, Yuko; Iwasaki, Genji; Fukaya, Hiroaki; Nonomura, Kazuhiko; Tanabe, Keiko; Koizumi, Shinichi; Uchiyama, Noriko; Bevan, Stuart J.; Malcangio, Marzia; Gentry, Clive; Fox, Alyson J.; Yaqoob, Mohammed; Culshaw, Andrew J.; Hallett, Allan.

In: Journal of Medicinal Chemistry, Vol. 51, No. 18, 25.09.2008, p. 5502-5505.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal