Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 5502-5505 |
| Journal / Publication | Journal of Medicinal Chemistry |
| Volume | 51 |
| Issue number | 18 |
| Publication status | Published - 25 Sept 2008 |
| Externally published | Yes |
Link(s)
Abstract
Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the efficacy of selective cathepsin S inhibitors as antihyperalgesics in a model of neuropathic pain in rats after oral administration. © 2008 American Chemical Society.
Citation Format(s)
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. / Irie, Osamu; Kosaka, Takatoshi; Ehara, Takeru et al.
In: Journal of Medicinal Chemistry, Vol. 51, No. 18, 25.09.2008, p. 5502-5505.
In: Journal of Medicinal Chemistry, Vol. 51, No. 18, 25.09.2008, p. 5502-5505.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
