Dioxin-like potency of HO-and MeO-analogues of PBDEs' the potential risk through consumption of fish from eastern china

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Guanyong Su
  • Jie Xia
  • Hongling Liu
  • Hongxia Yu
  • John P. Giesy
  • Xiaowei Zhang

Detail(s)

Original languageEnglish
Pages (from-to)10781-10788
Journal / PublicationEnvironmental Science and Technology
Volume46
Issue number19
Publication statusPublished - 2 Oct 2012

Abstract

Polybrominated diphenyl ethers (PBDEs) and their analogues, such as hydroxylated PBDE (HO-PBDEs) and methoxylated PBDE (MeO-PBDEs) are of interest due to their wide distribution, bioaccumulation and potential toxicity to humans and wildlife. While information on the toxicity/biological potencies of PBDEs was available, information on analogues of PBDEs was limited. Dioxin-like toxicity of 34 PBDEs analogues was evaluated by use of the H4IIE-luc, rat hepatoma transactivation bioassay in 384-well plate format at concentrations ranging from 0 to 10 000 ng/mL. Among the 34 target analogues of PBDEs studied here, 19 activated the aryl hydrocarbon receptor (AhR) and induced significant dioxin-like responses in H4IIE-luc cells. Efficacies of the analogues of PBDEs ranged from 5.0% to 101.8% of the maximum response caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD-max) and their respective 2,3,7,8-TCDD potency factors (RePH4IIE-luc) ranged from 7.35 × 10 -12 to 4.00 × 10-4, some of which were equal to or more potent than some mono-ortho-substituted PCBs (TEF-WHO = 3 × 10-5). HO-PBDEs exhibited greater dioxin-like activity than did the corresponding MeO-PBDEs. Analogues of PBDEs were detected mostly in marine organisms. Of these 11 detected analogues of PBDEs, 6 were found to have measurable dioxin-like potency. Though some analogues of PBDEs exhibited significant dioxin-like potency as measured by responses of the H4IIE-luc transactivation assay, concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (PBDEs analoguesTEQH4IIE-luc), calculated as the sum of the product of concentrations of individual PBDE and their RePH4IIE-luc, were less than the tolerance limit proposed by European Union and the oral reference dose (RfD) derived by U.S. Environmental Protection Agency, respectively. (Hazard Quotients (HQ) <0.005) Additional investigations should be conducted to evaluate the toxic potencies of these chemicals, especially for 2'-MeO-BDE-28, 4-HO-BDE-90, 6-HO-BDE-47, and 6-MeO-BDE-47, which had been detected in other environmental media, including human blood. © 2012 American Chemical Society.

Citation Format(s)

Dioxin-like potency of HO-and MeO-analogues of PBDEs' the potential risk through consumption of fish from eastern china. / Su, Guanyong; Xia, Jie; Liu, Hongling; Lam, Michael H. W.; Yu, Hongxia; Giesy, John P.; Zhang, Xiaowei.

In: Environmental Science and Technology, Vol. 46, No. 19, 02.10.2012, p. 10781-10788.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review