Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

14 Scopus Citations
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Author(s)

  • Jie Xia
  • Guanyong Su
  • Xiaowei Zhang
  • Wei Shi
  • John P. Giesy
  • And 1 others
  • Hongxia Yu

Detail(s)

Original languageEnglish
Pages (from-to)1480-1488
Journal / PublicationEnvironmental Science and Pollution Research
Volume21
Issue number2
Online published8 Aug 2013
Publication statusPublished - Jan 2014

Abstract

Deterioration of the general ecosystem and specifically quality of the water in Tai Lake (Ch: Taihu), the third largest freshwater in China, is of great concern. However, knowledge on status and trends of dioxin-like compounds in Tai Lake was limited. This study investigated AhR-mediated potency and quantified potential aryl hydrocarbon receptor (AhR) agonists in sediments from four regions (Meiliang Bay, Zhushan Lake, Lake Center, Corner of Zhushan Lake, and Meiliang Bay) of Tai Lake by use of the in vitro H4IIE-luc, cell-based, transactivation, reporter gene assay, and instrumental analysis. Concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (Bio-TEQs) in sediments ranged from less than the limit of detection to 114.5 pg/g, dry weight, which indicated that organic extracts of sediments exhibited significant AhR-mediated potencies. Results of the potency balance analysis demonstrated that acid-labile, dioxin-like compounds represented a greater proportion of concentrations of Bio-TEQs in sediments from Tai Lake. Concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents calculated as the sum of the product of concentrations of individual congeners and their respective relative potencies (Chem-TEQs) based on polycyclic aromatic hydrocarbons and/or polychlorinated biphenyls represented no more than 10 % of the total concentrations of Bio-TEQs. © 2013 Springer-Verlag Berlin Heidelberg.

Research Area(s)

  • AhR agonist, Asia, In vitro bioassay, Toxicant equivalents

Citation Format(s)

Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists. / Xia, Jie; Su, Guanyong; Zhang, Xiaowei; Shi, Wei; Giesy, John P.; Yu, Hongxia.

In: Environmental Science and Pollution Research, Vol. 21, No. 2, 01.2014, p. 1480-1488.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review