DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER

Jiao Zhai; Yanwei Jia; Pui-In Mak; Rui P. Martins

DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER

Jiao Zhai
, Yanwei Jia^*
, Pui-In Mak
, Rui P. Martins

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Screening drugs on biopsies from cancer patients can promote precision medicine, but is challenging due to limited tumor samples for cancer patients (especially at an early stage). With the advantage of small samples needed, digital microfluidics (DMF) emerged to be very prominent platform for drug screening. In this paper, a DMF platform was developed, for drug screening of primary biopsy samples from xenograft mouse breast cancer models. The on-chip individual mouse drug screening results matched well with the individual in-vivo tumor response, suggesting the effectiveness for rapid determination of the optimal effective drug for personalized cancer therapies based on DMF platform.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)
Publisher	Chemical and Biological Microsystems Society
Pages	742-743
ISBN (Print)	9781733419000, 9781713818526
Publication status	Published - Oct 2019
Externally published	Yes
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019) - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 https://cbmsociety.org/microtas/microtas2019/

Publication series

Name	International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)
Abbreviated title	MicroTAS 2019
Place	Switzerland
City	Basel
Period	27/10/19 → 31/10/19
Internet address	https://cbmsociety.org/microtas/microtas2019/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Digital Microfluidics
Drug Screening
Precision Medicine

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Zhai, J., Jia, Y., Mak, P.-I., & Martins, R. P. (2019). DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019) (pp. 742-743). (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS). Chemical and Biological Microsystems Society.

Zhai, Jiao ; Jia, Yanwei ; Mak, Pui-In et al. / DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society, 2019. pp. 742-743 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

@inproceedings{69af95dad6e8402d99ac385769c2c20c,

title = "DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER",

abstract = "Screening drugs on biopsies from cancer patients can promote precision medicine, but is challenging due to limited tumor samples for cancer patients (especially at an early stage). With the advantage of small samples needed, digital microfluidics (DMF) emerged to be very prominent platform for drug screening. In this paper, a DMF platform was developed, for drug screening of primary biopsy samples from xenograft mouse breast cancer models. The on-chip individual mouse drug screening results matched well with the individual in-vivo tumor response, suggesting the effectiveness for rapid determination of the optimal effective drug for personalized cancer therapies based on DMF platform.",

keywords = "Digital Microfluidics, Drug Screening, Precision Medicine",

author = "Jiao Zhai and Yanwei Jia and Pui-In Mak and Martins, \{Rui P.\}",

year = "2019",

month = oct,

language = "English",

isbn = "9781733419000",

series = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS",

publisher = "Chemical and Biological Microsystems Society",

pages = "742--743",

booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

url = "https://cbmsociety.org/microtas/microtas2019/",

}

Zhai, J, Jia, Y, Mak, P-I & Martins, RP 2019, DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, Chemical and Biological Microsystems Society, pp. 742-743, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), Basel, Switzerland, 27/10/19.

DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER. / Zhai, Jiao; Jia, Yanwei; Mak, Pui-In et al.
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society, 2019. p. 742-743 (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER

AU - Zhai, Jiao

AU - Jia, Yanwei

AU - Mak, Pui-In

AU - Martins, Rui P.

PY - 2019/10

Y1 - 2019/10

N2 - Screening drugs on biopsies from cancer patients can promote precision medicine, but is challenging due to limited tumor samples for cancer patients (especially at an early stage). With the advantage of small samples needed, digital microfluidics (DMF) emerged to be very prominent platform for drug screening. In this paper, a DMF platform was developed, for drug screening of primary biopsy samples from xenograft mouse breast cancer models. The on-chip individual mouse drug screening results matched well with the individual in-vivo tumor response, suggesting the effectiveness for rapid determination of the optimal effective drug for personalized cancer therapies based on DMF platform.

AB - Screening drugs on biopsies from cancer patients can promote precision medicine, but is challenging due to limited tumor samples for cancer patients (especially at an early stage). With the advantage of small samples needed, digital microfluidics (DMF) emerged to be very prominent platform for drug screening. In this paper, a DMF platform was developed, for drug screening of primary biopsy samples from xenograft mouse breast cancer models. The on-chip individual mouse drug screening results matched well with the individual in-vivo tumor response, suggesting the effectiveness for rapid determination of the optimal effective drug for personalized cancer therapies based on DMF platform.

KW - Digital Microfluidics

KW - Drug Screening

KW - Precision Medicine

UR - https://www.scopus.com/pages/publications/85094950698

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85094950698&origin=recordpage

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781733419000

SN - 9781713818526

T3 - International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

SP - 742

EP - 743

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

PB - Chemical and Biological Microsystems Society

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

Y2 - 27 October 2019 through 31 October 2019

ER -

Zhai J, Jia Y, Mak PI, Martins RP. DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019). Chemical and Biological Microsystems Society. 2019. p. 742-743. (International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS).

DIGITAL MICROFLUIDIC DRUG SCREENING ON BIOPSIES FROM XENOGRAFT MOUSE BREAST CANCER

Abstract

Publication series

Conference

UN SDGs

Research Keywords

Other Access Options

Permanent Link

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