Diffusion tensor imaging reveals changes in the adult rat brain following long-term and passive moderate acoustic exposure

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Sherwin Abdoli
  • Leon C. Ho
  • Jevin W. Zhang
  • Celia M. Dong
  • Ed X. Wu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)4540-4547
Journal / PublicationJournal of the Acoustical Society of America
Volume140
Issue number6
Publication statusPublished - 1 Dec 2016

Abstract

This study investigated neuroanatomical changes following long-term acoustic exposure at moderate sound pressure level (SPL) under passive conditions, without coupled behavioral training. The authors utilized diffusion tensor imaging (DTI) to detect morphological changes in white matter. DTIs from adult rats (n = 8) exposed to continuous acoustic exposure at moderate SPL for 2 months were compared with DTIs from rats (n = 8) reared under standard acoustic conditions. Two distinct forms of DTI analysis were applied in a sequential manner. First, DTI images were analyzed using voxel-based statistics which revealed greater fractional anisotropy (FA) of the pyramidal tract and decreased FA of the tectospinal tract and trigeminothalamic tract of the exposed rats. Region of interest analysis confirmed (p <0.05) that FA had increased in the pyramidal tract but did not show a statistically significant difference in the FA of the tectospinal or trigeminothalamic tract. The results of the authors show that long-term and passive acoustic exposure at moderate SPL increases the organization of white matter in the pyramidal tract.

Citation Format(s)

Diffusion tensor imaging reveals changes in the adult rat brain following long-term and passive moderate acoustic exposure. / Abdoli, Sherwin; Ho, Leon C.; Zhang, Jevin W.; Dong, Celia M.; Lau, Condon; Wu, Ed X.

In: Journal of the Acoustical Society of America, Vol. 140, No. 6, 01.12.2016, p. 4540-4547.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal