Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Susanna K.P. Lau
  • Antonio C.P. Wong
  • Hayes K.H. Luk
  • Kenneth S.M. Li
  • Joshua Fung
  • Zirong He
  • Flora K.K. Cheng
  • Tony T.Y. Chan
  • Stella Chu
  • Kam Leng Aw-Yong
  • Kitty S.C. Fung
  • Patrick C.Y. Woo

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)2961-2965
Journal / PublicationEmerging Infectious Diseases
Volume26
Issue number12
Publication statusPublished - Dec 2020

Link(s)

Abstract

Severe acute respiratory syndrome coronavirus 2 did riot replicate efficiently in 13 bat cell lines whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinalophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

Research Area(s)

  • CORONAVIRUS

Bibliographic Note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

Citation Format(s)

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells. / Lau, Susanna K.P.; Wong, Antonio C.P.; Luk, Hayes K.H.; Li, Kenneth S.M.; Fung, Joshua; He, Zirong; Cheng, Flora K.K.; Chan, Tony T.Y.; Chu, Stella; Aw-Yong, Kam Leng; Lau, Terrence C.K.; Fung, Kitty S.C.; Woo, Patrick C.Y.

In: Emerging Infectious Diseases, Vol. 26, No. 12, 12.2020, p. 2961-2965.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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