Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Susanna K.P. Lau; Antonio C.P. Wong; Hayes K.H. Luk; Kenneth S.M. Li; Joshua Fung; Zirong He; Flora K.K. Cheng; Tony T.Y. Chan; Stella Chu; Kam Leng Aw-Yong; Terrence C.K. Lau; Kitty S.C. Fung; Patrick C.Y. Woo

doi:10.3201/eid2612.202308

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Susanna K.P. Lau^* (Co-first Author)
, Antonio C.P. Wong (Co-first Author)
, Hayes K.H. Luk (Co-first Author)
, Kenneth S.M. Li
, Joshua Fung
, Zirong He
, Flora K.K. Cheng
, Tony T.Y. Chan
, Stella Chu
, Kam Leng Aw-Yong
, Terrence C.K. Lau
, Kitty S.C. Fung
, Patrick C.Y. Woo^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

14 Citations (Scopus)

74 Downloads (CityUHK Scholars)

Abstract

Severe acute respiratory syndrome coronavirus 2 did riot replicate efficiently in 13 bat cell lines whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinalophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

Original language	English
Pages (from-to)	2961-2965
Journal	Emerging Infectious Diseases
Volume	26
Issue number	12
DOIs	https://doi.org/10.3201/eid2612.202308
Publication status	Published - Dec 2020

Bibliographical note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

CORONAVIRUS

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED FINAL PUBLISHED VERSION FILE: All materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs, are in the public domain and can be reprinted or used without permission with proper citation. All content is freely available without charge to the user or their institution. In accordance with the Budapest Open Access Initiative definition of open access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set forth by Creative Commons.

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10.3201/eid2612.202308

73358186.pdfFinal Published version, 1.87 MB

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Cite this

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title = "Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells",

abstract = "Severe acute respiratory syndrome coronavirus 2 did riot replicate efficiently in 13 bat cell lines whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinalophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.",

keywords = "CORONAVIRUS",

author = "Lau, \{Susanna K.P.\} and Wong, \{Antonio C.P.\} and Luk, \{Hayes K.H.\} and Li, \{Kenneth S.M.\} and Joshua Fung and Zirong He and Cheng, \{Flora K.K.\} and Chan, \{Tony T.Y.\} and Stella Chu and Aw-Yong, \{Kam Leng\} and Lau, \{Terrence C.K.\} and Fung, \{Kitty S.C.\} and Woo, \{Patrick C.Y.\}",

note = "Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).",

year = "2020",

month = dec,

doi = "10.3201/eid2612.202308",

language = "English",

volume = "26",

pages = "2961--2965",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "12",

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AU - Wong, Antonio C.P.

AU - Luk, Hayes K.H.

AU - Li, Kenneth S.M.

AU - Fung, Joshua

AU - He, Zirong

AU - Cheng, Flora K.K.

AU - Chan, Tony T.Y.

AU - Chu, Stella

AU - Aw-Yong, Kam Leng

AU - Lau, Terrence C.K.

AU - Fung, Kitty S.C.

AU - Woo, Patrick C.Y.

N1 - Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

PY - 2020/12

Y1 - 2020/12

N2 - Severe acute respiratory syndrome coronavirus 2 did riot replicate efficiently in 13 bat cell lines whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinalophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

AB - Severe acute respiratory syndrome coronavirus 2 did riot replicate efficiently in 13 bat cell lines whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinalophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

KW - CORONAVIRUS

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U2 - 10.3201/eid2612.202308

DO - 10.3201/eid2612.202308

M3 - RGC 21 - Publication in refereed journal

C2 - 32730733

SN - 1080-6040

VL - 26

SP - 2961

EP - 2965

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 12

ER -

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Abstract

Bibliographical note

UN SDGs

Research Keywords

Publisher's Copyright Statement

Policy Impact

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Other Access Options

Permanent Link

Other Files and Links

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TBRS-ExtU-Lead: Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus

Cite this

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Abstract

Bibliographical note

UN SDGs

Research Keywords

Publisher's Copyright Statement

Policy Impact

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

TBRS-ExtU-Lead: Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus

Cite this