Differential single living cell refractometry using grating resonant cavity with optical trap

L. K. Chin; A. Q. Liu; C. S. Lim; X. M. Zhang; J. H. Ng; J. Z. Hao; S. Takahashi

doi:10.1063/1.2823610

Differential single living cell refractometry using grating resonant cavity with optical trap

L. K. Chin, A. Q. Liu, C. S. Lim, X. M. Zhang, J. H. Ng, J. Z. Hao, S. Takahashi

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

65 Citations (Scopus)

Abstract

This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage. © 2007 American Institute of Physics.

Original language	English
Article number	243901
Journal	Applied Physics Letters
Volume	91
Issue number	24
DOIs	https://doi.org/10.1063/1.2823610
Publication status	Published - 2007
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Differential single living cell refractometry using grating resonant cavity with optical trap",

abstract = "This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage. {\textcopyright} 2007 American Institute of Physics.",

author = "Chin, {L. K.} and Liu, {A. Q.} and Lim, {C. S.} and Zhang, {X. M.} and Ng, {J. H.} and Hao, {J. Z.} and S. Takahashi",

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doi = "10.1063/1.2823610",

language = "English",

volume = "91",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics",

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T1 - Differential single living cell refractometry using grating resonant cavity with optical trap

AU - Chin, L. K.

AU - Liu, A. Q.

AU - Lim, C. S.

AU - Zhang, X. M.

AU - Ng, J. H.

AU - Hao, J. Z.

AU - Takahashi, S.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2007

Y1 - 2007

N2 - This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage. © 2007 American Institute of Physics.

AB - This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage. © 2007 American Institute of Physics.

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U2 - 10.1063/1.2823610

DO - 10.1063/1.2823610

M3 - RGC 21 - Publication in refereed journal

SN - 0003-6951

VL - 91

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 24

M1 - 243901

ER -

Differential single living cell refractometry using grating resonant cavity with optical trap

Abstract

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