Differential responses of female and male brains to hypoxia in the marine medaka Oryzias melastigma

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

7 Scopus Citations
View graph of relations

Author(s)

  • Jing-Woei Li
  • Anna Chung-Kwan Tse
  • Simon Yuan Wang
  • Ting-Fung Chan
  • Rudolf Shiu-Sun Wu

Detail(s)

Original languageEnglish
Pages (from-to)36-43
Journal / PublicationAquatic Toxicology
Volume172
Publication statusPublished - 1 Mar 2016

Abstract

Hypoxia, an endocrine disruptor, affects synthesis and balance of sex steroid hormones, leading to reproductive impairment in both female and male fish. Cumulating reports demonstrated the alternation of hypothalamus-pituitary-gonad axis (HPG-axis) by hypoxia. However, the detail mechanism underlying how hypoxia may alter other brain functions remains largely unknown. In this report, we used marine medaka as a model and conducted a high-throughput RNA sequencing followed by bioinformatics analysis on hypoxia-exposed brain tissues, aiming to determine the change of transcriptional signature and to unravel the pathways that are induced by hypoxia. We found that hypoxia lead to dysregulation of brain functions (including synaptic transmission, axon guidance, potassium ion transport, neuron differentiation, and development of brain and pituitary gland), and also signaling pathways (e.g., gap junction, calcium signaling pathway, and GnRH signaling pathway). Our results further demonstrate gender-specific responses to hypoxia in female and male fish's brains, which provides novel insights into the mechanism underlying the hypoxia induced sex specific brain functions impairments.

Research Area(s)

  • Brain, Hypoxia, Medaka, Synaptic transmission, Transcriptome

Citation Format(s)

Differential responses of female and male brains to hypoxia in the marine medaka Oryzias melastigma. / Lai, Keng-Po; Li, Jing-Woei; Tse, Anna Chung-Kwan; Wang, Simon Yuan; Chan, Ting-Fung; Wu, Rudolf Shiu-Sun.

In: Aquatic Toxicology, Vol. 172, 01.03.2016, p. 36-43.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review