Differential Adsorption of L- and D-Lysine on Achiral MFI Zeolites as Determined by Synchrotron X-Ray Powder Diffraction and Thermogravimetric Analysis

Reported here is the first crystallographic observation of stereospecific bindings of L- and D-lysine (Lys) in achiral MFI zeolites. The MFI structure offers inherent geometric and internal confinement effects for the enantiomeric difference in L- and D-Lys adsorption. Notable differences have been observed by circular dichroism (CD) spectroscopy and thermogravimetric analysis (TGA). Distinct L- and D-Lys adsorption behaviours on the H-ZSM-5 framework have been revealed by the Rietveld refinement of high-resolution synchrotron X-ray powder diffraction (SXRD) data and the density-functional theory (DFT) calculations. Despite demonstrating the approach for L- and D-Lys over MFI zeolites at an atomistic resolution, the differential adsorption study sheds light on the rational engineering of molecular interaction(s) with achiral microporous materials for chiral separation purposes. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim