Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hui Wang
  • Yansong Xue
  • Hanying Zhang
  • Yan Huang
  • Min Du
  • Mei-Jun Zhu

Detail(s)

Original languageEnglish
Pages (from-to)2253-2257
Number of pages5
Journal / PublicationMolecular Nutrition and Food Research
Volume57
Issue number12
Online published21 Aug 2013
Publication statusPublished - Dec 2013
Externally publishedYes

Abstract

Grape seed extract (GSE) is a by-product of the wine industry, with abundant polyphenolic compounds known for their anti-inflammatory and anti-oxidative effects. Using IL10-deficient mice (IL10KO), here we showed that GSE (1% of dry feed weight) ameliorated inflammatory bowel disease indices, increased colonic goblet cell numbers and decreased myeloperoxidase levels in the large intestine. Concomitantly, GSE supplementation attenuated inflammation, decreased the expression of pore forming tight junction protein claudin2, and increased levels of Lactobacilli and Bacteroides in the gut microbiota of IL10KO mice. In summary, our study shows that GSE has protective roles on inflammatory bowel disease through altering gut inflammation, tight junction protein expression, and gut microbiota composition.

Research Area(s)

  • Epithelium, Grape seed extract, Inflammatory bowel disease, Intestine, IL-10, Microbiota

Citation Format(s)

Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. / Wang, Hui; Xue, Yansong; Zhang, Hanying et al.
In: Molecular Nutrition and Food Research, Vol. 57, No. 12, 12.2013, p. 2253-2257.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review