Diamond-like carbon coating and surface grafting of osteoprotegerin and alendronate on polyetheretherketone to ameliorate the mechanical performance and osseointegration simultaneously

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Junfeng Chen
  • Lingxia Xie
  • Qing Liao
  • Shi Mo
  • Yuanliang Lv
  • Liping Tong
  • Huaiyu Wang
  • Xiaoming Li

Detail(s)

Original languageEnglish
Article number109815
Journal / PublicationComposites Part B: Engineering
Volume236
Online published17 Mar 2022
Publication statusPublished - 1 May 2022

Abstract

Polyetheretherketone (PEEK) is an alternative to biomedical metals for fabricating bone implants, which possesses many advantages but its clinical applications are still impeded by the considerable release of worn debris and inferior osseointegration after long-term implantation. To circumvent these problems, in this study, diamond-like carbon (DLC) coating is initially fabricated on PEEK using C2H2 + Ar plasma immersion ion implantation (PIII), and then the targeted biomolecules including osteoprotegerin (OPG) and alendronate (ALN) are simultaneously grafted onto the outer surface of DLC-coated sample by a two-step treatment consisting of N2 PIII activation and solution immersion. On one hand, DLC coating can improve the wear resistance of PEEK substrate by surface hardening. On the other hand, the introduced OPG and ALN tune the biological performances in vitro and in vivo from many aspects such as immunomodulation, anti-osteoclastogenesis and pro-osteogenesis. Collectively, our study presents a feasible one-stop solution as “deposition-activation-incubation” for the surface multi-functionalization of PEEK implants, which has a broad application prospect also due to the clean approach and excellent versatility.

Research Area(s)

  • Diamond-like carbon, Orthopedic implants, Osseointegration, Polyetheretherketone, Surface modification

Citation Format(s)

Diamond-like carbon coating and surface grafting of osteoprotegerin and alendronate on polyetheretherketone to ameliorate the mechanical performance and osseointegration simultaneously. / Chen, Junfeng; Xie, Lingxia; Ruan, Qingdong; Gao, Ang; Liao, Qing; Mo, Shi; Lv, Yuanliang; Tong, Liping; Wang, Huaiyu; Chu, Paul K.; Li, Xiaoming.

In: Composites Part B: Engineering, Vol. 236, 109815, 01.05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review