D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Lin Chen
  • Zhiliang Wei
  • Yuguo Li
  • Kapil Suchal
  • Sheng Bi
  • Xiang Xu
  • Philip C Wong
  • Hanzhang Lu
  • Peter CM van Zijl
  • Tong Li
  • Jiadi Xu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)1013-1025
Journal / PublicationJournal of Cerebral Blood Flow and Metabolism
Volume41
Issue number5
Online published16 Jul 2020
Publication statusPublished - May 2021

Abstract

In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.

Research Area(s)

  • Alzheimer’s diseases, chemical exchange saturation transfer, dynamic glucose enhanced, Glucose uptake, on-resonance variable delay multiple pulse, tau pathology

Citation Format(s)

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI. / Chen, Lin; Wei, Zhiliang; Chan, Kannie WY; Li, Yuguo; Suchal, Kapil; Bi, Sheng; Huang, Jianpan; Xu, Xiang; Wong, Philip C; Lu, Hanzhang; van Zijl, Peter CM; Li, Tong; Xu, Jiadi.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 41, No. 5, 05.2021, p. 1013-1025.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review