DGE-MRI detects the therapeutic effect of IL-33 in Alzheimer’s mice by assessing cerebral glucose uptake and clearance at 3T

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Pages1938
Publication statusPublished - May 2021

Conference

Title2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting
LocationOnline
Period15 - 20 May 2021

Abstract

We have demonstrated that D-glucose kinetics detected by dynamic glucose-enhanced (DGE)-MRI can be used to assess D-glucose uptake and clearance alterations in Alzheimer’s disease (AD) mice at 3T. Interleukin (IL)-33 treatment has been shown to promote Aβ clearance. Here, we applied our established DGE-MRI to detect changes of brain clearance after IL-33 treatment in cerebrospinal fluid (CSF) and brain parenchyma in AD mice. A significant increased D-glucose clearance from CSF, but not brain parenchyma, was observed after treatment. DGE-MRI provides a non-invasive evaluation of IL-33 treatment in AD, and further affirm its potential to assess brain lymphatic system in AD.

Citation Format(s)

DGE-MRI detects the therapeutic effect of IL-33 in Alzheimer’s mice by assessing cerebral glucose uptake and clearance at 3T. / Chen, Zilin; Huang, Jianpan; Liu, Yang; Lai, Joseph H. C.; Chan, Kannie W. Y.

2021. 1938 Paper presented at 2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting, .

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review