Development of Novel Implants with Self-Antibacterial Performance through In-Situ Growth of 1D ZnO Nanowire
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 623-633 |
Journal / Publication | Colloids and Surfaces B: Biointerfaces |
Volume | 141 |
Online published | 18 Feb 2016 |
Publication status | Published - 1 May 2016 |
Link(s)
Abstract
To prevent the attachment of bacteria to implant surfaces, the 1D zinc oxide nanowire-coating has been successfully developed on material surfaces by using a custom-made hydrothermal approach. The chemical nature, surface topography and wettability of spike-like 1D ZnO nanowire-coating are comprehensively investigated. The anti-adhesive and antimicrobial properties of 1D nanowire-coating are tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by using in vitro live/dead staining and scanning electron microscopy. We find that the adhesion of bacteria can be reduced via the special spike-like topography and that the release of Zn2+ ions can help suppress the growth of attached bacteria. Furthermore, the antimicrobial effect is also evaluated under in vivo conditions by using a rat model infected with bioluminescent S. aureus. The amount of live bacteria in the rat implanted with a nanowire-coated sample is less than that of the control at various time points. Hence, it is believed that the nanowire-coated material is promising for application in orthopaedic implantation after the long-term animal studies have been completed.
Research Area(s)
- ZnO nanowire, Self-antibacterial effect, Surface modification, Bioluminescent bacteria
Citation Format(s)
Development of Novel Implants with Self-Antibacterial Performance through In-Situ Growth of 1D ZnO Nanowire. / Wang, Wenhao; Li, Tak Lung; Wong, Hoi Man et al.
In: Colloids and Surfaces B: Biointerfaces, Vol. 141, 01.05.2016, p. 623-633.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review