Development of a high throughput robot-aided cell injection system for human cells

Yu Ting Chow; Shuxun Chen; Chong Liu; Shuk Han Cheng; Ronald A. Li; Dong Sun

doi:10.1109/ICRA.2014.6906970

Development of a high throughput robot-aided cell injection system for human cells

Yu Ting Chow
, Shuxun Chen
, Chong Liu
, Shuk Han Cheng
, Ronald A. Li
, Dong Sun

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

4 Citations (Scopus)

Abstract

Few of the current injection technologies can be applied to those human cells whose diameters are ranged about 10-25 (im only. This paper reports our most recent effort in developing a robot-aided microinjection system to solve the challenging problem of automated injection on human cells. A unique microfluidic cell holding chip is designed and fabricated to trap the single cells in the predefined docking area. Imaging processing technique is used to recognize automatically the target cells to be injected. A microrobot system equipped with a micropipette is used to perform the injection tasks on these target cells. Injection experiments on human embryonic stem cells (hESCs) (ranged about 17-25μm) are performed to demonstrate the effectiveness of the proposed microinjection system.

Original language	English
Title of host publication	Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA)
Publisher	IEEE
Pages	963-968
ISBN (Electronic)	9781479936854
ISBN (Print)	9781479936861
DOIs	https://doi.org/10.1109/ICRA.2014.6906970
Publication status	Published - Jun 2014
Event	2014 IEEE International Conference on Robotics and Automation (ICRA 2014) - Hong Kong Convention and Exhibition Centre, Hong Kong, China Duration: 31 May 2014 → 7 Jun 2014 http://www.icra2014.com/

Publication series

Name	Proceedings - IEEE International Conference on Robotics and Automation
Publisher	Institute of Electrical and Electronics Engineers Inc.
Volume	2014
ISSN (Print)	1050-4729

Conference

Conference	2014 IEEE International Conference on Robotics and Automation (ICRA 2014)
Abbreviated title	ICRA 2014
Place	China
City	Hong Kong
Period	31/05/14 → 7/06/14
Internet address	http://www.icra2014.com/

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10.1109/ICRA.2014.6906970

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Chow, Y. T., Chen, S., Liu, C., Cheng, S. H., Li, R. A., & Sun, D. (2014). Development of a high throughput robot-aided cell injection system for human cells. In Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA) (pp. 963-968). (Proceedings - IEEE International Conference on Robotics and Automation; Vol. 2014). IEEE. https://doi.org/10.1109/ICRA.2014.6906970

@inproceedings{1fa07c9fe87a4782b622a338ff04b085,

title = "Development of a high throughput robot-aided cell injection system for human cells",

abstract = "Few of the current injection technologies can be applied to those human cells whose diameters are ranged about 10-25 (im only. This paper reports our most recent effort in developing a robot-aided microinjection system to solve the challenging problem of automated injection on human cells. A unique microfluidic cell holding chip is designed and fabricated to trap the single cells in the predefined docking area. Imaging processing technique is used to recognize automatically the target cells to be injected. A microrobot system equipped with a micropipette is used to perform the injection tasks on these target cells. Injection experiments on human embryonic stem cells (hESCs) (ranged about 17-25μm) are performed to demonstrate the effectiveness of the proposed microinjection system.",

author = "Chow, \{Yu Ting\} and Shuxun Chen and Chong Liu and Cheng, \{Shuk Han\} and Li, \{Ronald A.\} and Dong Sun",

year = "2014",

month = jun,

doi = "10.1109/ICRA.2014.6906970",

language = "English",

isbn = "9781479936861",

series = "Proceedings - IEEE International Conference on Robotics and Automation",

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pages = "963--968",

booktitle = "Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA)",

address = "United States",

note = "2014 IEEE International Conference on Robotics and Automation (ICRA 2014), ICRA 2014 ; Conference date: 31-05-2014 Through 07-06-2014",

url = "http://www.icra2014.com/",

}

Chow, YT, Chen, S, Liu, C, Cheng, SH, Li, RA & Sun, D 2014, Development of a high throughput robot-aided cell injection system for human cells. in Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA). Proceedings - IEEE International Conference on Robotics and Automation, vol. 2014, IEEE, pp. 963-968, 2014 IEEE International Conference on Robotics and Automation (ICRA 2014), Hong Kong, China, 31/05/14. https://doi.org/10.1109/ICRA.2014.6906970

Development of a high throughput robot-aided cell injection system for human cells. / Chow, Yu Ting; Chen, Shuxun; Liu, Chong et al.
Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA). IEEE, 2014. p. 963-968 (Proceedings - IEEE International Conference on Robotics and Automation; Vol. 2014).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Development of a high throughput robot-aided cell injection system for human cells

AU - Chow, Yu Ting

AU - Chen, Shuxun

AU - Liu, Chong

AU - Cheng, Shuk Han

AU - Li, Ronald A.

AU - Sun, Dong

PY - 2014/6

Y1 - 2014/6

N2 - Few of the current injection technologies can be applied to those human cells whose diameters are ranged about 10-25 (im only. This paper reports our most recent effort in developing a robot-aided microinjection system to solve the challenging problem of automated injection on human cells. A unique microfluidic cell holding chip is designed and fabricated to trap the single cells in the predefined docking area. Imaging processing technique is used to recognize automatically the target cells to be injected. A microrobot system equipped with a micropipette is used to perform the injection tasks on these target cells. Injection experiments on human embryonic stem cells (hESCs) (ranged about 17-25μm) are performed to demonstrate the effectiveness of the proposed microinjection system.

AB - Few of the current injection technologies can be applied to those human cells whose diameters are ranged about 10-25 (im only. This paper reports our most recent effort in developing a robot-aided microinjection system to solve the challenging problem of automated injection on human cells. A unique microfluidic cell holding chip is designed and fabricated to trap the single cells in the predefined docking area. Imaging processing technique is used to recognize automatically the target cells to be injected. A microrobot system equipped with a micropipette is used to perform the injection tasks on these target cells. Injection experiments on human embryonic stem cells (hESCs) (ranged about 17-25μm) are performed to demonstrate the effectiveness of the proposed microinjection system.

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DO - 10.1109/ICRA.2014.6906970

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781479936861

T3 - Proceedings - IEEE International Conference on Robotics and Automation

SP - 963

EP - 968

BT - Proceedings - 2014 IEEE International Conference on Robotics and Automation (ICRA)

PB - IEEE

T2 - 2014 IEEE International Conference on Robotics and Automation (ICRA 2014)

Y2 - 31 May 2014 through 7 June 2014

ER -

Development of a high throughput robot-aided cell injection system for human cells

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