Develop CEST-detectable liposomes for nose-to-brain drug delivery

Research output: Conference PapersAbstractpeer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - May 2022

Conference

Title2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting
LocationHybrid
PlaceUnited Kingdom
CityLondon
Period7 - 12 May 2022

Abstract

Nose-to-brain-drug-delivery is an effective route to administer drug to the brain bypassing the blood-brain-barrier(BBB). No non-invasive way to assess the delivery-efficiency available yet, especially with brain distribution. Here we investigated the imaging of nanomedicine-delivery via intranasal-administration using CEST-detectable(Iohexol loaded)mucus-penetrating-liposome(with10%PEG). The mucus-retention and penetration-efficiency was examined by in-vitro cell study and in-vivo CEST MRI after injecting the Iohexol-loaded-mucus-penetrating-liposome(Ioh-Lipo). 10%PEG-Ioh-Lipo showed a 20%higher mucus-retention than 1%PEG-Ioh-Lipo. This was also observed in-vivo with significant CEST-contrast difference in the OB between 3groups of mice at 4.3 and 3.5ppm. Moreover, liposomes were mainly found in the ONL, EPL, and MCL of the OB in histology.

Citation Format(s)

Develop CEST-detectable liposomes for nose-to-brain drug delivery. / LAW, Lok Hin; Huang, Jianpan; Liu, Yang et al.
2022. Abstract from 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, London, United Kingdom.

Research output: Conference PapersAbstractpeer-review