Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Jiaqi LIU; Chi Tim LEUNG; Luyun LIANG; Yuqin WANG; Jian CHEN; Keng Po LAI; William Ka Fai TSE

doi:10.3390/cancers14143547

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Jiaqi LIU, Chi Tim LEUNG, Luyun LIANG, Yuqin WANG, Jian CHEN^*, Keng Po LAI, William Ka Fai TSE^*

^*Corresponding author for this work

Department of Chemistry

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

25 Citations (Scopus)

55 Downloads (CityUHK Scholars)

Abstract

Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

Original language	English
Article number	3547
Journal	Cancers
Volume	14
Issue number	14
Online published	21 Jul 2022
DOIs	https://doi.org/10.3390/cancers14143547
Publication status	Published - Jul 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

proliferation
metastasis
apoptosis
PROMOTES CELL-MIGRATION
KAPPA-B ACTIVATION
HEPATOCELLULAR-CARCINOMA
COLORECTAL-CANCER
ANDROGEN RECEPTOR
PANCREATIC-CANCER
DOWN-REGULATION
TUMOR-SUPPRESSOR
PROSTATE-CANCER
C-MYC

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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abstract = "Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.",

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author = "Jiaqi LIU and LEUNG, {Chi Tim} and Luyun LIANG and Yuqin WANG and Jian CHEN and LAI, {Keng Po} and TSE, {William Ka Fai}",

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AU - LIU, Jiaqi

AU - LEUNG, Chi Tim

AU - LIANG, Luyun

AU - WANG, Yuqin

AU - CHEN, Jian

AU - LAI, Keng Po

AU - TSE, William Ka Fai

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KW - metastasis

KW - apoptosis

KW - PROMOTES CELL-MIGRATION

KW - KAPPA-B ACTIVATION

KW - HEPATOCELLULAR-CARCINOMA

KW - COLORECTAL-CANCER

KW - ANDROGEN RECEPTOR

KW - PANCREATIC-CANCER

KW - DOWN-REGULATION

KW - TUMOR-SUPPRESSOR

KW - PROSTATE-CANCER

KW - C-MYC

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M3 - RGC 21 - Publication in refereed journal

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Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Abstract

UN SDGs

Research Keywords

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