Deubiquitinases in Cancers : Aspects of Proliferation, Metastasis, and Apoptosis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Jiaqi LIU
  • Chi Tim LEUNG
  • Luyun LIANG
  • Yuqin WANG
  • Jian CHEN
  • And 2 others
  • Keng Po LAI
  • William Ka Fai TSE

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number3547
Journal / PublicationCancers
Volume14
Issue number14
Online published21 Jul 2022
Publication statusPublished - Jul 2022

Link(s)

Abstract

Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

Research Area(s)

  • proliferation, metastasis, apoptosis, PROMOTES CELL-MIGRATION, KAPPA-B ACTIVATION, HEPATOCELLULAR-CARCINOMA, COLORECTAL-CANCER, ANDROGEN RECEPTOR, PANCREATIC-CANCER, DOWN-REGULATION, TUMOR-SUPPRESSOR, PROSTATE-CANCER, C-MYC

Citation Format(s)

Deubiquitinases in Cancers : Aspects of Proliferation, Metastasis, and Apoptosis. / LIU, Jiaqi; LEUNG, Chi Tim; LIANG, Luyun et al.

In: Cancers, Vol. 14, No. 14, 3547, 07.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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