Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator

Hellas C.M. Yau; Hing Leung Chan; Mengsu Yang

doi:10.1016/S0925-4005(01)00967-4

Author(s)

Hellas C.M. Yau
Hing Leung Chan
Mengsu Yang

Detail(s)

Original language	English
Pages (from-to)	283-288
Journal / Publication	Sensors and Actuators, B: Chemical
Volume	81
Issue number	2-3
Publication status	Published - 5 Jan 2002

Link(s)

DOI	DOI https://doi.org/10.1016/S0925-4005(01)00967-4 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-0037021781&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(e2dbf791-5398-4282-a54a-cc06756cf31b).html

Abstract

Quartz crystal resonator (QCR) was used to identify the mode of interactions between small DNA-binding molecules and calf thymus DNA (ctDNA) according to the alteration of the relative viscosity of the solution. The differential series resonant frequencies of a 10-MHz QCR mounted in a cell containing DNA and various DNA-binding molecules at different concentrations including DNA-intercalators: ethidium bromide (EB), planar platinum(II) quaterpyridine complex, [Pt(QP)](CF ₃SO ₃) ₂ (QP=2,2′:6′,2″:6″,2″ ′-quaterpyridine), ruthenium(II) quinonediimine complex of cyclam (cyclam=1,4,8,11-tetraazacyclotetradecane), [Ru(cyclam)(pqdi)]·(ClO ₄) ₂ (pqdi=9,10-phenanthroquinonediimine, pqdi) as well as groove binder, Hoechst 33342, separately were measured. Compared to traditional viscosity measurement method, the use of QCR has the benefits of automation, time saving, high sensitivity and stability, as well as easy operation and cleanup. Extreme viscous sample can also be conducted by QCR. © 2002 Elsevier Science B.V. All rights reserved.

Research Area(s)

DNA, Intercalators, Quartz crystal resonator, Viscosity

Citation Format(s)

[ RIS ] [ BibTeX ]

Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator. / Yau, Hellas C.M.; Chan, Hing Leung; Yang, Mengsu.
In: Sensors and Actuators, B: Chemical, Vol. 81, No. 2-3, 05.01.2002, p. 283-288.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Yau, HCM, Chan, HL & Yang, M 2002, 'Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator', Sensors and Actuators, B: Chemical, vol. 81, no. 2-3, pp. 283-288. https://doi.org/10.1016/S0925-4005(01)00967-4

Yau, H. C. M., Chan, H. L., & Yang, M. (2002). Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator. Sensors and Actuators, B: Chemical, 81(2-3), 283-288. https://doi.org/10.1016/S0925-4005(01)00967-4

Yau HCM, Chan HL, Yang M. Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator. Sensors and Actuators, B: Chemical. 2002 Jan 5;81(2-3):283-288. doi: 10.1016/S0925-4005(01)00967-4

Yau, Hellas C.M. ; Chan, Hing Leung ; Yang, Mengsu. / Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator. In: Sensors and Actuators, B: Chemical. 2002 ; Vol. 81, No. 2-3. pp. 283-288.