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Detection of tandem repeats in DNA sequences based on parametric spectral estimation

Research output: Journal Publications and ReviewsRGC 22 - Publication in policy or professional journal

Abstract

Tandem repeats, which occur frequently in genomes, are related to gene regulatory functions and various diseases. In this paper, an efficient algorithm for tandem repeat detection is proposed. In our method, the spectrogram of a DNA sequence is analyzed based on the autoregressive model. Then, significant peaks in the spectrogram are selected, and the corresponding regions in the DNA sequence are analyzed to search for tandem repeats. Experiment results show that our method has a superior performance in comparison with other algorithms. © 2009 IEEE.
Original languageEnglish
Pages (from-to)747-755
JournalIEEE Transactions on Information Technology in Biomedicine
Volume13
Issue number5
DOIs
Publication statusPublished - 2009

Research Keywords

  • Autoregressive (AR) model
  • DNA sequence analysis
  • Spectral analysis
  • Tandem repeats

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