Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Article numbera032284
Journal / PublicationCold Spring Harbor perspectives in biology
Volume10
Issue number7
Publication statusPublished - Jul 2018

Abstract

RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.

Citation Format(s)

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome. / Kwok, Chun Kit; Marsico, Giovanni; Balasubramanian, Shankar.

In: Cold Spring Harbor perspectives in biology, Vol. 10, No. 7, a032284, 07.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review