Design principles of microneedles for drug delivery and sampling applications

Zhicheng Le; Jinming Yu; Ying Jie Quek; Bingyu Bai; Xianlei Li; Yufeng Shou; Ba Myint; Chenjie Xu; Andy Tay

doi:10.1016/j.mattod.2022.10.025

Design principles of microneedles for drug delivery and sampling applications

Zhicheng Le, Jinming Yu, Ying Jie Quek, Bingyu Bai, Xianlei Li, Yufeng Shou, Ba Myint, Chenjie Xu, Andy Tay^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

79 Citations (Scopus)

Abstract

Microneedles technology is a powerful platform to achieve efficient transdermal delivery of bioactive molecules for local or systemic therapies attributing to their minimally invasive delivery mode that circumvents the use of hypodermic needles. Building on its success in transdermal delivery, the applications of microneedles have been expanded to non-dermatological purposes including oral, buccal, intramyocardial, and ocular delivery. Additionally, with the advancement of materials and analysis techniques, microneedle-integrated point-of-care devices have shown promise for fast and efficient biomolecular sampling for patient health monitoring and disease diagnosis. In this review, we discuss the design principles of microneedles to overcome the biological barriers of various administration routes for drug delivery, in addition to more recent innovations employing microneedles for biomolecular and cellular sampling applications.

Original language	English
Pages (from-to)	137-169
Number of pages	33
Journal	Materials Today
Volume	63
Online published	17 Nov 2022
DOIs	https://doi.org/10.1016/j.mattod.2022.10.025
Publication status	Published - Mar 2023

Funding

Andy Tay acknowledges funding support from the NUS Presidential Young Professorship, Ministry of Education Tier 1, National Medical Research Council Open-Fund Young Investigator Research Grant, Technological Innovations in Infectious Diseases Translational Research Programme, and Institute for Health Innovation & Technology. Chenjie Xu appreciates the support by Start-up Grant for New Faculty (9610472) and Strategic Interdisciplinary Research Grant (7020029) from City University of Hong Kong, General Research Fund (GRF) grant from the Research Grants Council (RGC) of the Hong Kong Special Administrative Region China (CityU 100168), and the Mainland/Hong Kong Joint Research Scheme sponsored by the RGC Hong Kong and the National Natural Science Foundation of China (N_CityU118/20). Fig. 2 and Fig. 5 were designed by BioRender.com. We would like to thank the illustrator, Zac Goh, for help with Fig. 3.

Research Keywords

Biological barriers
Design principles
Drug delivery
Microneedle
Sampling

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title = "Design principles of microneedles for drug delivery and sampling applications",

abstract = "Microneedles technology is a powerful platform to achieve efficient transdermal delivery of bioactive molecules for local or systemic therapies attributing to their minimally invasive delivery mode that circumvents the use of hypodermic needles. Building on its success in transdermal delivery, the applications of microneedles have been expanded to non-dermatological purposes including oral, buccal, intramyocardial, and ocular delivery. Additionally, with the advancement of materials and analysis techniques, microneedle-integrated point-of-care devices have shown promise for fast and efficient biomolecular sampling for patient health monitoring and disease diagnosis. In this review, we discuss the design principles of microneedles to overcome the biological barriers of various administration routes for drug delivery, in addition to more recent innovations employing microneedles for biomolecular and cellular sampling applications.",

keywords = "Biological barriers, Design principles, Drug delivery, Microneedle, Sampling",

author = "Zhicheng Le and Jinming Yu and Quek, {Ying Jie} and Bingyu Bai and Xianlei Li and Yufeng Shou and Ba Myint and Chenjie Xu and Andy Tay",

year = "2023",

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doi = "10.1016/j.mattod.2022.10.025",

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journal = "Materials Today",

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AU - Le, Zhicheng

AU - Yu, Jinming

AU - Quek, Ying Jie

AU - Bai, Bingyu

AU - Li, Xianlei

AU - Shou, Yufeng

AU - Myint, Ba

AU - Xu, Chenjie

AU - Tay, Andy

PY - 2023/3

Y1 - 2023/3

N2 - Microneedles technology is a powerful platform to achieve efficient transdermal delivery of bioactive molecules for local or systemic therapies attributing to their minimally invasive delivery mode that circumvents the use of hypodermic needles. Building on its success in transdermal delivery, the applications of microneedles have been expanded to non-dermatological purposes including oral, buccal, intramyocardial, and ocular delivery. Additionally, with the advancement of materials and analysis techniques, microneedle-integrated point-of-care devices have shown promise for fast and efficient biomolecular sampling for patient health monitoring and disease diagnosis. In this review, we discuss the design principles of microneedles to overcome the biological barriers of various administration routes for drug delivery, in addition to more recent innovations employing microneedles for biomolecular and cellular sampling applications.

AB - Microneedles technology is a powerful platform to achieve efficient transdermal delivery of bioactive molecules for local or systemic therapies attributing to their minimally invasive delivery mode that circumvents the use of hypodermic needles. Building on its success in transdermal delivery, the applications of microneedles have been expanded to non-dermatological purposes including oral, buccal, intramyocardial, and ocular delivery. Additionally, with the advancement of materials and analysis techniques, microneedle-integrated point-of-care devices have shown promise for fast and efficient biomolecular sampling for patient health monitoring and disease diagnosis. In this review, we discuss the design principles of microneedles to overcome the biological barriers of various administration routes for drug delivery, in addition to more recent innovations employing microneedles for biomolecular and cellular sampling applications.

KW - Biological barriers

KW - Design principles

KW - Drug delivery

KW - Microneedle

KW - Sampling

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U2 - 10.1016/j.mattod.2022.10.025

DO - 10.1016/j.mattod.2022.10.025

M3 - RGC 21 - Publication in refereed journal

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VL - 63

SP - 137

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JO - Materials Today

JF - Materials Today

ER -

Design principles of microneedles for drug delivery and sampling applications

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NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

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Design principles of microneedles for drug delivery and sampling applications

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NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

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