TY - JOUR
T1 - Design of portable electrochemiluminescence sensing systems for point-of-care-testing applications
AU - Xia, Shuqi
AU - Pan, Jiangfei
AU - Dai, Deshen
AU - Dai, Zong
AU - Yang, Mengsu
AU - Yi, Changqing
PY - 2023/5
Y1 - 2023/5
N2 - Point-of-care testing (POCT) technology is highly desirable for clinical diagnosis, healthcare monitoring, food safety inspection, and environment surveillance, because it enables rapid detection anywhere, anytime, and by anyone. Electrochemiluminescence (ECL) has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity, simplicity, rapidity and easy to control, and is now attracting increasing attention for POCT applications. However, to realize the accurate on-site quantitation, it is still challenging to develop portable devices which can precisely collect, analyze, transmit and display the ECL signals. This review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by part. Then the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail, followed by offering future perspectives. We attempted to provide an appealing viewpoint to inspire interested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization. © 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
AB - Point-of-care testing (POCT) technology is highly desirable for clinical diagnosis, healthcare monitoring, food safety inspection, and environment surveillance, because it enables rapid detection anywhere, anytime, and by anyone. Electrochemiluminescence (ECL) has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity, simplicity, rapidity and easy to control, and is now attracting increasing attention for POCT applications. However, to realize the accurate on-site quantitation, it is still challenging to develop portable devices which can precisely collect, analyze, transmit and display the ECL signals. This review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by part. Then the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail, followed by offering future perspectives. We attempted to provide an appealing viewpoint to inspire interested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization. © 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
KW - Aggregation-induced ECL
KW - Bipolar electrode
KW - Machine learning
KW - Microfluidics
KW - Nanoscale ECL luminophores
KW - Screen-printed electrode
KW - Smartphone
UR - http://www.scopus.com/inward/record.url?scp=85149009562&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85149009562&origin=recordpage
U2 - 10.1016/j.cclet.2022.107799
DO - 10.1016/j.cclet.2022.107799
M3 - RGC 21 - Publication in refereed journal
SN - 1001-8417
VL - 34
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 5
M1 - 107799
ER -