Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of α-dehydro amino ketones

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Shuang Gao
  • Chunyan Yang
  • Qiwei Lang
  • Xiaobing Ding
  • Gen-Qiang Chen
  • Xumu Zhang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)2847-2851
Journal / PublicationScience China Chemistry
Volume66
Issue number10
Online published19 Sept 2023
Publication statusPublished - Oct 2023

Abstract

A series of novel atropisomeric diphosphine ligands termed TanPhos were designed and synthesized, which has a smaller bite angle compared with that of other ligands such as BINAP. TanPhos showed high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of a-dehydro amino ketones, and up 99% yield and 99% ee were obtained for a wide range of chiral α-amino ketones. [Figure not available: see fulltext.] © 2023, Science China Press.

Research Area(s)

  • asymmetric hydrogenation, chiral ligand, diphosphine

Citation Format(s)

Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of α-dehydro amino ketones. / Tan, Xuefeng; Gao, Shuang; Yang, Chunyan et al.
In: Science China Chemistry, Vol. 66, No. 10, 10.2023, p. 2847-2851.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review