Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

3 Scopus Citations
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Author(s)

  • Rui Wang
  • Qing-Xuan Zheng
  • Wei Wang
  • Hui-Jing Li
  • Qi-Yong Huai

Detail(s)

Original languageEnglish
Pages (from-to)703-710
Journal / PublicationBiological and Pharmaceutical Bulletin
Volume40
Issue number5
Publication statusPublished - Feb 2017

Abstract

A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC50 values of 23.34 μM on Hep-G2 cells, 12.23 μM on MCF-7 cells, and 44.47 μM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.

Research Area(s)

  • Anticancer, Glycyrrhetinic acid, Oleanolic acid, Synthesis

Citation Format(s)

Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids. / Wang, Rui; Zheng, Qing-Xuan; Wang, Wei; Feng, Ling; Li, Hui-Jing; Huai, Qi-Yong.

In: Biological and Pharmaceutical Bulletin, Vol. 40, No. 5, 02.2017, p. 703-710.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal