Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation

Hoon Yoo; Keerthi S. Guruge; Noriko Yamanaka; Chihiro Sato; Osamu Mikami; Shigeru Miyazaki; Nobuyoshi Yamashita; John P. Giesy

doi:10.1016/j.ecoenv.2007.09.007

Author(s)

Hoon Yoo
Keerthi S. Guruge
Noriko Yamanaka
Chihiro Sato
Osamu Mikami
And 3 others

Shigeru Miyazaki
Nobuyoshi Yamashita
John P. Giesy

Detail(s)

Original language	English
Pages (from-to)	26-36
Journal / Publication	Ecotoxicology and Environmental Safety
Volume	72
Issue number	1
Publication status	Published - Jan 2009

Link(s)

DOI	DOI https://doi.org/10.1016/j.ecoenv.2007.09.007 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-54049113521&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(a578e1a6-b0bb-4923-ba21-757465d3a35a).html

Abstract

Elimination kinetics and tissue disposition of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in male chickens (Gallus gallus) was determined following exposure by subcutaneous implantation. Chickens were exposed to two levels of PFOA or PFOS for 4 wk and then allowed to depurate for an additional 4 wk. These exposures did not cause any statistically significant changes in body index, clinical biochemistry or histology among treatments relative to the controls (p>0.05), except that concentrations of total cholesterol and phospholipids were less in chickens exposed to PFOS. The elimination rate constant for PFOA (0.150±0.010 d^-1) was approximately six-fold greater than that of PFOS (0.023±0.004 d^-1). The greatest concentrations of PFOA and PFOS were found in kidney and liver, respectively. The organ to blood ratio of PFOS concentration was increased after the whole experiment, indicating the importance of organ partitioning of PFOS in elimination kinetics. The depuration half-life of PFOA (t_1/2=4.6 d) and PFOS (t_1/2=125 d) in chickens was calculated. © 2007 Elsevier Inc. All rights reserved.

Research Area(s)

Avian, Chicken, Elimination, Kidney, Liver, Perfluoroocatne sulfonate, Perflurooctanoic acid, Tissue disposition

Citation Format(s)

[ RIS ] [ BibTeX ]

Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation. / Yoo, Hoon; Guruge, Keerthi S.; Yamanaka, Noriko et al.
In: Ecotoxicology and Environmental Safety, Vol. 72, No. 1, 01.2009, p. 26-36.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Yoo, H, Guruge, KS, Yamanaka, N, Sato, C, Mikami, O, Miyazaki, S, Yamashita, N & Giesy, JP 2009, 'Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation', Ecotoxicology and Environmental Safety, vol. 72, no. 1, pp. 26-36. https://doi.org/10.1016/j.ecoenv.2007.09.007

Yoo, H., Guruge, K. S., Yamanaka, N., Sato, C., Mikami, O., Miyazaki, S., Yamashita, N., & Giesy, J. P. (2009). Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation. Ecotoxicology and Environmental Safety, 72(1), 26-36. https://doi.org/10.1016/j.ecoenv.2007.09.007

Yoo H, Guruge KS, Yamanaka N, Sato C, Mikami O, Miyazaki S et al. Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation. Ecotoxicology and Environmental Safety. 2009 Jan;72(1):26-36. doi: 10.1016/j.ecoenv.2007.09.007

Yoo, Hoon ; Guruge, Keerthi S. ; Yamanaka, Noriko et al. / Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation. In: Ecotoxicology and Environmental Safety. 2009 ; Vol. 72, No. 1. pp. 26-36.