Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging–Guided Combination Therapy of Tumors

Shiyi Lu; Xin Li; Jiulong Zhang; Chen Peng; Mingwu Shen; Xiangyang Shi

doi:10.1002/advs.201801612

Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging–Guided Combination Therapy of Tumors

Shiyi Lu (Co-first Author)
, Xin Li (Co-first Author)
, Jiulong Zhang
, Chen Peng^*
, Mingwu Shen^*
, Xiangyang Shi^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

134 Citations (Scopus)

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Abstract

Development of multifunctional theranostic nanoplatforms with improved diagnostic sensitivity and therapeutic efficiency of tumors still remains a great challenge. A unique multifunctional theranostic nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer–stabilized gold nanoflowers (NFs) embedded with ultrasmall iron oxide (USIO) nanoparticles (NPs) for multimode T₁-weighted magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging–guided combination photothermal therapy (PTT) and radiotherapy (RT) of tumors is reported here. G5 dendrimer–stabilized Au NPs and citric acid–stabilized USIO NPs are separately prepared, the two particles under a certain Fe/Au molar ratio are mixed to form complexes, the complexes are exposed to Au growth solution to form NFs via a seed–mediated manner, and the remaining dendrimer terminal amines are acetylated. The formed dendrimer-stabilized Fe₃O₄/Au NFs (for short, Fe₃O₄/Au DSNFs) have a mean diameter of 99.8 nm, display good colloidal stability and cytocompatibility, and exhibit a near-infrared absorption feature. The unique structure and composition of the Fe₃O₄/Au DSNFs endows them with a high r₁ relaxivity (3.22 mM⁻¹ s⁻¹) and photothermal conversion efficiency (82.7%), affording their uses as a theranostic nanoplatform for multimode MR/CT/PA imaging and combination PTT/RT of tumors with improved therapeutic efficacy, which is important for translational nanomedicine applications.

© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English
Article number	1801612
Number of pages	9
Journal	Advanced Science
Volume	5
Issue number	12
Online published	12 Nov 2018
DOIs	https://doi.org/10.1002/advs.201801612
Publication status	Published - Dec 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

This work was supported financially by the National Natural Science Foundation of China (81761148028 and 21773026), the Fundamental Research Funds for the Central Universities (for X.S., M.S., and C.P.), and the Science and Technology Commission of Shanghai Municipality (17540712000 and 15520711400).

Research Keywords

combination therapy
dendrimers
gold nanoflowers
multimode imaging
ultrasmall iron oxide nanoparticles

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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title = "Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging–Guided Combination Therapy of Tumors",

abstract = "Development of multifunctional theranostic nanoplatforms with improved diagnostic sensitivity and therapeutic efficiency of tumors still remains a great challenge. A unique multifunctional theranostic nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer–stabilized gold nanoflowers (NFs) embedded with ultrasmall iron oxide (USIO) nanoparticles (NPs) for multimode T1-weighted magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging–guided combination photothermal therapy (PTT) and radiotherapy (RT) of tumors is reported here. G5 dendrimer–stabilized Au NPs and citric acid–stabilized USIO NPs are separately prepared, the two particles under a certain Fe/Au molar ratio are mixed to form complexes, the complexes are exposed to Au growth solution to form NFs via a seed–mediated manner, and the remaining dendrimer terminal amines are acetylated. The formed dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs) have a mean diameter of 99.8 nm, display good colloidal stability and cytocompatibility, and exhibit a near-infrared absorption feature. The unique structure and composition of the Fe3O4/Au DSNFs endows them with a high r1 relaxivity (3.22 mM−1 s−1) and photothermal conversion efficiency (82.7\%), affording their uses as a theranostic nanoplatform for multimode MR/CT/PA imaging and combination PTT/RT of tumors with improved therapeutic efficacy, which is important for translational nanomedicine applications. {\textcopyright} 2018 The Authors. Published by WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

keywords = "combination therapy, dendrimers, gold nanoflowers, multimode imaging, ultrasmall iron oxide nanoparticles",

author = "Shiyi Lu and Xin Li and Jiulong Zhang and Chen Peng and Mingwu Shen and Xiangyang Shi",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Published by WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = dec,

doi = "10.1002/advs.201801612",

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Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging–Guided Combination Therapy of Tumors. / Lu, Shiyi (Co-first Author); Li, Xin (Co-first Author); Zhang, Jiulong et al.
In: Advanced Science, Vol. 5, No. 12, 1801612, 12.2018.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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AU - Lu, Shiyi

AU - Li, Xin

AU - Zhang, Jiulong

AU - Peng, Chen

AU - Shen, Mingwu

AU - Shi, Xiangyang

PY - 2018/12

Y1 - 2018/12

N2 - Development of multifunctional theranostic nanoplatforms with improved diagnostic sensitivity and therapeutic efficiency of tumors still remains a great challenge. A unique multifunctional theranostic nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer–stabilized gold nanoflowers (NFs) embedded with ultrasmall iron oxide (USIO) nanoparticles (NPs) for multimode T1-weighted magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging–guided combination photothermal therapy (PTT) and radiotherapy (RT) of tumors is reported here. G5 dendrimer–stabilized Au NPs and citric acid–stabilized USIO NPs are separately prepared, the two particles under a certain Fe/Au molar ratio are mixed to form complexes, the complexes are exposed to Au growth solution to form NFs via a seed–mediated manner, and the remaining dendrimer terminal amines are acetylated. The formed dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs) have a mean diameter of 99.8 nm, display good colloidal stability and cytocompatibility, and exhibit a near-infrared absorption feature. The unique structure and composition of the Fe3O4/Au DSNFs endows them with a high r1 relaxivity (3.22 mM−1 s−1) and photothermal conversion efficiency (82.7%), affording their uses as a theranostic nanoplatform for multimode MR/CT/PA imaging and combination PTT/RT of tumors with improved therapeutic efficacy, which is important for translational nanomedicine applications. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - Development of multifunctional theranostic nanoplatforms with improved diagnostic sensitivity and therapeutic efficiency of tumors still remains a great challenge. A unique multifunctional theranostic nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer–stabilized gold nanoflowers (NFs) embedded with ultrasmall iron oxide (USIO) nanoparticles (NPs) for multimode T1-weighted magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging–guided combination photothermal therapy (PTT) and radiotherapy (RT) of tumors is reported here. G5 dendrimer–stabilized Au NPs and citric acid–stabilized USIO NPs are separately prepared, the two particles under a certain Fe/Au molar ratio are mixed to form complexes, the complexes are exposed to Au growth solution to form NFs via a seed–mediated manner, and the remaining dendrimer terminal amines are acetylated. The formed dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs) have a mean diameter of 99.8 nm, display good colloidal stability and cytocompatibility, and exhibit a near-infrared absorption feature. The unique structure and composition of the Fe3O4/Au DSNFs endows them with a high r1 relaxivity (3.22 mM−1 s−1) and photothermal conversion efficiency (82.7%), affording their uses as a theranostic nanoplatform for multimode MR/CT/PA imaging and combination PTT/RT of tumors with improved therapeutic efficacy, which is important for translational nanomedicine applications. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

KW - combination therapy

KW - dendrimers

KW - gold nanoflowers

KW - multimode imaging

KW - ultrasmall iron oxide nanoparticles

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DO - 10.1002/advs.201801612

M3 - RGC 21 - Publication in refereed journal

C2 - 30581720

AN - SCOPUS:85056463756

SN - 2198-3844

VL - 5

JO - Advanced Science

JF - Advanced Science

IS - 12

M1 - 1801612

ER -

Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging–Guided Combination Therapy of Tumors

Abstract

Bibliographical note

Funding

Research Keywords

Publisher's Copyright Statement

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