Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Zhongjun Zhou
  • Masayuki Doi
  • Jianming Wang
  • Renhai Cao
  • Baohua Liu
  • Jarkko Kortesmaa
  • Lydia Sorokin
  • Yihai Cao
  • Karl Tryggvason

Detail(s)

Original languageEnglish
Pages (from-to)4059-4063
Journal / PublicationCancer Research
Volume64
Issue number12
Publication statusPublished - 15 Jun 2004
Externally publishedYes

Abstract

Laminin-8 (α4β1γ1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin α4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin α4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.

Citation Format(s)

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice. / Zhou, Zhongjun; Doi, Masayuki; Wang, Jianming; Cao, Renhai; Liu, Baohua; Chan, Kui Ming; Kortesmaa, Jarkko; Sorokin, Lydia; Cao, Yihai; Tryggvason, Karl.

In: Cancer Research, Vol. 64, No. 12, 15.06.2004, p. 4059-4063.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal