Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Zhongjun Zhou; Masayuki Doi; Jianming Wang; Renhai Cao; Baohua Liu; Kui Ming Chan; Jarkko Kortesmaa; Lydia Sorokin; Yihai Cao; Karl Tryggvason

doi:10.1158/0008-5472.CAN-04-0291

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Zhongjun Zhou^*, Masayuki Doi, Jianming Wang, Renhai Cao, Baohua Liu, Kui Ming Chan, Jarkko Kortesmaa, Lydia Sorokin, Yihai Cao, Karl Tryggvason

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

34 Citations (Scopus)

Abstract

Laminin-8 (α4β1γ1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin α4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin α4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.

Original language	English
Pages (from-to)	4059-4063
Journal	Cancer Research
Volume	64
Issue number	12
DOIs	https://doi.org/10.1158/0008-5472.CAN-04-0291
Publication status	Published - 15 Jun 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access Output

10.1158/0008-5472.CAN-04-0291

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{3cefa8ab412c43ad918bfcba30433c57,

title = "Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice",

abstract = "Laminin-8 (α4β1γ1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin α4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin α4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.",

author = "Zhongjun Zhou and Masayuki Doi and Jianming Wang and Renhai Cao and Baohua Liu and Chan, {Kui Ming} and Jarkko Kortesmaa and Lydia Sorokin and Yihai Cao and Karl Tryggvason",

year = "2004",

month = jun,

day = "15",

doi = "10.1158/0008-5472.CAN-04-0291",

language = "English",

volume = "64",

pages = "4059--4063",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research",

number = "12",

}

TY - JOUR

T1 - Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

AU - Zhou, Zhongjun

AU - Doi, Masayuki

AU - Wang, Jianming

AU - Cao, Renhai

AU - Liu, Baohua

AU - Chan, Kui Ming

AU - Kortesmaa, Jarkko

AU - Sorokin, Lydia

AU - Cao, Yihai

AU - Tryggvason, Karl

PY - 2004/6/15

Y1 - 2004/6/15

N2 - Laminin-8 (α4β1γ1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin α4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin α4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.

AB - Laminin-8 (α4β1γ1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin α4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin α4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.

UR - http://www.scopus.com/inward/record.url?scp=3042663099&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-3042663099&origin=recordpage

U2 - 10.1158/0008-5472.CAN-04-0291

DO - 10.1158/0008-5472.CAN-04-0291

M3 - RGC 21 - Publication in refereed journal

C2 - 15205311

SN - 0008-5472

VL - 64

SP - 4059

EP - 4063

JO - Cancer Research

JF - Cancer Research

IS - 12

ER -

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Abstract

UN SDGs

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this