Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Weicheng Shen
  • Tingting Hu
  • Xueyan Liu
  • Fanqi Meng
  • Zhikang Wu
  • Zhuolin Cui
  • Yu Yang
  • Hai Li
  • Qinghua Zhang
  • Lin Gu
  • Ruizheng Liang

Detail(s)

Original languageEnglish
Article number3384
Journal / PublicationNature Communications
Volume13
Online published13 Jun 2022
Publication statusPublished - 2022

Link(s)

Abstract

Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (similar to 97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation.

Research Area(s)

  • OXYGEN, NANOPLATFORM, GENERATION

Citation Format(s)

Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy. / Shen, Weicheng; Hu, Tingting; Liu, Xueyan; Zha, Jiajia; Meng, Fanqi; Wu, Zhikang; Cui, Zhuolin; Yang, Yu; Li, Hai; Zhang, Qinghua; Gu, Lin; Liang, Ruizheng; Tan, Chaoliang.

In: Nature Communications, Vol. 13, 3384, 2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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