Deep tissue photoacoustic computed tomography with a fast and compact laser system

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Depeng Wang
  • Yuehang Wang
  • Weiran Wang
  • Dandan Luo
  • Upendra Chitgupi
  • Jumin Geng
  • Yang Zhou
  • Jonathan F. Lovell
  • Jun Xia

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number#278767
Pages (from-to)112-123
Journal / PublicationBiomedical Optics Express
Volume8
Issue number1
Publication statusPublished - 1 Jan 2017

Abstract

Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 - 200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diodepumped laser used in this study had a miniature footprint (13 × 14 × 7 cm3), weighed only 1.6 kg, and outputted up to 80 mJ per pulse at 1064 nm. In vitro, the laser system readily provided over 4 cm PACT depth in chicken breast tissue. In vivo, in addition to high resolution, non-invasive brain imaging in living mice, the system can operate at 50 Hz, which enabled high-speed cross-sectional imaging of murine cardiac and respiratory function. The system also provided high quality, high-frame rate, and non-invasive three-dimensional mapping of arm, palm, and breast vasculature at multi centimeter depths in living human subjects, demonstrating the clinical viability of compact lasers for PACT.

Research Area(s)

  • Imaging systems, Lasers and laser optics, Photoacoustic imaging

Citation Format(s)

Deep tissue photoacoustic computed tomography with a fast and compact laser system. / Wang, Depeng; Wang, Yuehang; Wang, Weiran et al.
In: Biomedical Optics Express, Vol. 8, No. 1, #278767, 01.01.2017, p. 112-123.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review