Deep, sub-wavelength acoustic patterning of complex and non-periodic shapes on soft membranes supported by air cavities

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Kuan-Wen Tung
  • Pei-Shan Chung
  • Tianxing Man
  • Sidhant Tiwari
  • Ben Wu
  • Yuan-Fang Chou
  • Fu-ling Yang
  • Pei-Yu Chiou

Detail(s)

Original languageEnglish
Pages (from-to)3714-3725
Journal / PublicationLab on a Chip
Volume19
Issue number21
Early online date4 Oct 2019
Publication statusPublished - 7 Nov 2019

Abstract

Arbitrary patterning of micro-objects in liquid is crucial to many biomedical applications. Among conventional methodologies, acoustic approaches provide superior biocompatibility but are intrinsically limited toproducing periodic patterns at low resolution due to the nature of standing waves and the coupling between fluid and structure vibrations. This work demonstrates a near-field acoustic platform capable of synthesizing high resolution, complex and non-periodic energy potential wells. A thin and viscoelastic membrane is utilized to modulate the acoustic wavefront on a deep, sub-wavelength scale by suppressing thestructural vibration selectively on the platform. Using 3 MHz excitation (λ ∼ 500 μm in water), we have experimentally validated such a concept by realizing patterning of microparticles and cells with a line resolution of 50 μm (one tenth of the wavelength). Furthermore, massively parallel patterning across a 3 × 3 mm2area has been achieved. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products

Citation Format(s)

Deep, sub-wavelength acoustic patterning of complex and non-periodic shapes on soft membranes supported by air cavities. / Tung, Kuan-Wen; Chung, Pei-Shan; Wu, Cong; Man, Tianxing; Tiwari, Sidhant; Wu, Ben; Chou, Yuan-Fang; Yang, Fu-ling; Chiou, Pei-Yu.

In: Lab on a Chip, Vol. 19, No. 21, 07.11.2019, p. 3714-3725.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review