Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes

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Original languageEnglish
Pages (from-to)683-686
Journal / PublicationAngewandte Chemie - International Edition
Issue number2
Publication statusPublished - 7 Jan 2013
Externally publishedYes


Keeping a broad (RNA) perspective: Conventional biochemical detection systems only have a 100-fold linear response range. The range of potassium concentrations detected by an RNA G-quadruplex sequence can be broadened by intentionally populating multiple intermediate folding states (see scheme). The folding of the RNA G-quadruplexes was monitored by both circular dichroism and intrinsic fluorescence spectroscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • fluorescence, folding cooperativity, G-quadruplexes, RNA, RNA structures