Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 683-686 |
| Journal / Publication | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 2 |
| Publication status | Published - 7 Jan 2013 |
| Externally published | Yes |
Link(s)
Abstract
Keeping a broad (RNA) perspective: Conventional biochemical detection systems only have a 100-fold linear response range. The range of potassium concentrations detected by an RNA G-quadruplex sequence can be broadened by intentionally populating multiple intermediate folding states (see scheme). The folding of the RNA G-quadruplexes was monitored by both circular dichroism and intrinsic fluorescence spectroscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Research Area(s)
- fluorescence, folding cooperativity, G-quadruplexes, RNA, RNA structures
Citation Format(s)
Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes. / Kwok, Chun Kit; Sherlock, Madeline E.; Bevilacqua, Philip C.
In: Angewandte Chemie - International Edition, Vol. 52, No. 2, 07.01.2013, p. 683-686.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
