Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

  • Chenfei Lyu
  • Chencen Yu
  • Guanglong Sun
  • Yue Zhao
  • Ruolan Cai
  • Hao Sun
  • Xintai Wang
  • Guoqiang Jia
  • Lingzhu Fan
  • Lin Zhou
  • Ying Shen
  • Lixia Gao
  • Xinjian Li

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2203665
Journal / PublicationAdvanced Science
Volume10
Issue number1
Online published14 Jan 2022
Publication statusPublished - 4 Jan 2023

Link(s)

Abstract

The cerebellum is involved in encoding balance, posture, speed, and gravity during locomotion. However, most studies are carried out on flat surfaces, and little is known about cerebellar activity during free ambulation on slopes. Here, it has been imaged the neuronal activity of cerebellar molecular interneurons (MLIs) and Purkinje cells (PCs) using a miniaturized microscope while a mouse is walking on a slope. It has been found that the neuronal activity of vermal MLIs specifically enhanced during uphill and downhill locomotion. In addition, a subset of MLIs is activated during entire uphill or downhill positions on the slope and is modulated by the slope inclines. In contrast, PCs showed counter-balanced neuronal activity to MLIs, which reduced activity at the ramp peak. So, PCs may represent the ramp environment at the population level. In addition, chemogenetic inactivation of lobule V of the vermis impaired uphill locomotion. These results revealed a novel micro-circuit in the vermal cerebellum that regulates ambulatory behavior in 3D terrains.

Research Area(s)

  • cerebellum, downhill  locomotion, molecular interneurons, Purkinje cells, ramp walking, uphill  locomotion

Citation Format(s)

Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice. / Lyu, Chenfei; Yu, Chencen; Sun, Guanglong et al.
In: Advanced Science, Vol. 10, No. 1, 2203665, 04.01.2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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