TY - CHAP
T1 - Decellularized tissue matrix for stem cell and tissue engineering
AU - Lee, Jung Seung
AU - Choi, Yi Sun
AU - Cho, Seung-Woo
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2018
Y1 - 2018
N2 - Decellularization is a technique to remove cellular components from native tissues, which could reduce immune reactions to the scaffolds. Decellularized matrices are valuable for tissue engineering, as they preserve tissue-specific structural, mechanical, and biochemical microenvironments, while promoting cellular engraftment and functions in the matrix. So far, various tissues have been decellularized by combinations of mechanical, chemical, and enzymatic processes and utilized in preparing bioscaffolds to provide tissue-specific environments for various cell types, including primary cells, progenitor cells, and stem cells. In addition, decellularized matrices could be manipulated into several formats according to the final application, such as tissue-engineering scaffolds, artificial organs, cell culture matrices, and transplantation carriers. In this chapter, we describe various types of decellularized tissue matrices and their extensive use in regenerative medicine, including reconstruction of artificial organs and regeneration of damaged tissues. © Springer Nature Singapore Pte Ltd. 2018.
AB - Decellularization is a technique to remove cellular components from native tissues, which could reduce immune reactions to the scaffolds. Decellularized matrices are valuable for tissue engineering, as they preserve tissue-specific structural, mechanical, and biochemical microenvironments, while promoting cellular engraftment and functions in the matrix. So far, various tissues have been decellularized by combinations of mechanical, chemical, and enzymatic processes and utilized in preparing bioscaffolds to provide tissue-specific environments for various cell types, including primary cells, progenitor cells, and stem cells. In addition, decellularized matrices could be manipulated into several formats according to the final application, such as tissue-engineering scaffolds, artificial organs, cell culture matrices, and transplantation carriers. In this chapter, we describe various types of decellularized tissue matrices and their extensive use in regenerative medicine, including reconstruction of artificial organs and regeneration of damaged tissues. © Springer Nature Singapore Pte Ltd. 2018.
KW - Artificial organ
KW - Decellularization
KW - Organ transplantation
KW - Regenerative medicine
KW - Stem cell
KW - Tissue engineering
UR - https://www.scopus.com/pages/publications/85057112591
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85057112591&origin=recordpage
U2 - 10.1007/978-981-13-0445-3_10
DO - 10.1007/978-981-13-0445-3_10
M3 - RGC 12 - Chapter in an edited book (Author)
C2 - 30471032
VL - 1064
T3 - Advances in Experimental Medicine and Biology
SP - 161
EP - 180
BT - Advances in Experimental Medicine and Biology
PB - Springer New York
ER -