Decellularized tissue engineered hyaline cartilage graft for articular cartilage repair

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

7 Scopus Citations
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Author(s)

  • Xiaolei Nie
  • Yon Jin Chuah
  • Wenzhen Zhu
  • Pengfei He
  • Yvonne Peck

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number119821
Journal / PublicationBiomaterials
Volume235
Online published26 Jan 2020
Publication statusPublished - Mar 2020

Abstract

Articular cartilage repair has been a long-standing challenge in orthopaedic medicine due to the limited self-regenerative capability of cartilage tissue. Currently, cartilage lesions are often treated by microfracture or autologous chondrocyte implantation (ACI). However, these treatments are frequently reported to result in a mixture of the desired hyaline cartilage and mechanically inferior fibrocartilage. In this study, by combining the advantages of cartilage tissue engineering and decellularization technology, we developed a decellularized allogeneic hyaline cartilage graft, named dLhCG, which achieved superior efficacy in articular cartilage repair and surpassed living autologous chondrocyte-based cartilaginous engraftment and ACI. By the 6-month time point after implantation in porcine knee joints, the fine morphology, composition, phenotype, microstructure and mechanical properties of the regenerated hyaline-like cartilaginous neo-tissue have been demonstrated via histology, biochemical assays, DNA microarrays and mechanical tests. The articular cartilaginous engraftment with allogeneic dLhCG was indicated to be well consistent, compatible and integrated with the native cartilage of the host. The successful repair of articular chondral defects in large animal models suggests the readiness of allogeneic dLhCG for clinical trials.

Research Area(s)

  • Cartilage, Decellularization, Large animal model, Pre-clinical, Scaffold-free, Tissue engineering

Citation Format(s)

Decellularized tissue engineered hyaline cartilage graft for articular cartilage repair. / Nie, Xiaolei; Chuah, Yon Jin; Zhu, Wenzhen; He, Pengfei; Peck, Yvonne; Wang, Dong-An.

In: Biomaterials, Vol. 235, 119821, 03.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal