TY - JOUR
T1 - D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI
AU - Chen, Lin
AU - Wei, Zhiliang
AU - Chan, Kannie WY
AU - Li, Yuguo
AU - Suchal, Kapil
AU - Bi, Sheng
AU - Huang, Jianpan
AU - Xu, Xiang
AU - Wong, Philip C
AU - Lu, Hanzhang
AU - van Zijl, Peter CM
AU - Li, Tong
AU - Xu, Jiadi
PY - 2021/5
Y1 - 2021/5
N2 - In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.
AB - In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.
KW - Alzheimer’s diseases
KW - chemical exchange saturation transfer
KW - dynamic glucose enhanced
KW - Glucose uptake
KW - on-resonance variable delay multiple pulse
KW - tau pathology
KW - Alzheimer’s diseases
KW - chemical exchange saturation transfer
KW - dynamic glucose enhanced
KW - Glucose uptake
KW - on-resonance variable delay multiple pulse
KW - tau pathology
KW - Alzheimer’s diseases
KW - chemical exchange saturation transfer
KW - dynamic glucose enhanced
KW - Glucose uptake
KW - on-resonance variable delay multiple pulse
KW - tau pathology
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85088007895&origin=recordpage
U2 - 10.1177/0271678X20941264
DO - 10.1177/0271678X20941264
M3 - RGC 21 - Publication in refereed journal
C2 - 32669023
SN - 0271-678X
VL - 41
SP - 1013
EP - 1025
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 5
ER -