Cytotoxicity of nanoparticle-loaded polymer capsules

C. Kirchner; A. Muñoz Javier; A. S. Susha; A. L. Rogach; O. Kreft; G. B. Sukhorukov; W. J. Parak

doi:10.1016/j.talanta.2005.06.042

Cytotoxicity of nanoparticle-loaded polymer capsules

C. Kirchner
, A. Muñoz Javier
, A. S. Susha
, A. L. Rogach
, O. Kreft
, G. B. Sukhorukov
, W. J. Parak

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

124 Citations (Scopus)

Abstract

Cytotoxic effects of micrometer-sized polymer capsules composed out of alternating layers of polystyrenesulfonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability. © 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	486-491
Journal	Talanta
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/j.talanta.2005.06.042
Publication status	Published - 15 Sept 2005
Externally published	Yes

Research Keywords

Cytotoxicity
Nanoparticle
Polymer capsule

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10.1016/j.talanta.2005.06.042

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title = "Cytotoxicity of nanoparticle-loaded polymer capsules",

abstract = "Cytotoxic effects of micrometer-sized polymer capsules composed out of alternating layers of polystyrenesulfonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",

keywords = "Cytotoxicity, Nanoparticle, Polymer capsule",

author = "C. Kirchner and Javier, \{A. Mu{\~n}oz\} and Susha, \{A. S.\} and Rogach, \{A. L.\} and O. Kreft and Sukhorukov, \{G. B.\} and Parak, \{W. J.\}",

year = "2005",

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day = "15",

doi = "10.1016/j.talanta.2005.06.042",

language = "English",

volume = "67",

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journal = "Talanta",

issn = "0039-9140",

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TY - JOUR

T1 - Cytotoxicity of nanoparticle-loaded polymer capsules

AU - Kirchner, C.

AU - Javier, A. Muñoz

AU - Susha, A. S.

AU - Rogach, A. L.

AU - Kreft, O.

AU - Sukhorukov, G. B.

AU - Parak, W. J.

PY - 2005/9/15

Y1 - 2005/9/15

N2 - Cytotoxic effects of micrometer-sized polymer capsules composed out of alternating layers of polystyrenesulfonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability. © 2005 Elsevier B.V. All rights reserved.

AB - Cytotoxic effects of micrometer-sized polymer capsules composed out of alternating layers of polystyrenesulfonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability. © 2005 Elsevier B.V. All rights reserved.

KW - Cytotoxicity

KW - Nanoparticle

KW - Polymer capsule

UR - https://www.scopus.com/pages/publications/24144468683

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-24144468683&origin=recordpage

U2 - 10.1016/j.talanta.2005.06.042

DO - 10.1016/j.talanta.2005.06.042

M3 - RGC 21 - Publication in refereed journal

SN - 0039-9140

VL - 67

SP - 486

EP - 491

JO - Talanta

JF - Talanta

IS - 3

ER -

Cytotoxicity of nanoparticle-loaded polymer capsules

Abstract

Research Keywords

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