Cytotoxic cycloartane triterpene saponins from Actaea asiatica

Jingchun Gao; Feng Huang; Jinchao Zhang; Guoyuan Zhu; Mengsu Yang; Peigen Xiao

doi:10.1021/np060113h

Cytotoxic cycloartane triterpene saponins from Actaea asiatica

Jingchun Gao
, Feng Huang
, Jinchao Zhang
, Guoyuan Zhu
, Mengsu Yang^*
, Peigen Xiao^*

^*Corresponding author for this work

CityUHK Shenzhen Research Institute

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

42 Citations (Scopus)

Abstract

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-D-xyloside (5), and 25-annydrocimigenol-β-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. © 2006 American Chemical Society and American Society of Pharmacognosy.

Original language	English
Pages (from-to)	1500-1502
Journal	Journal of Natural Products
Volume	69
Issue number	10
Online published	12 Sept 2006
DOIs	https://doi.org/10.1021/np060113h
Publication status	Published - Oct 2006

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SDG 3 Good Health and Well-being

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title = "Cytotoxic cycloartane triterpene saponins from Actaea asiatica",

abstract = "Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-D-xyloside (5), and 25-annydrocimigenol-β-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. {\textcopyright} 2006 American Chemical Society and American Society of Pharmacognosy.",

author = "Jingchun Gao and Feng Huang and Jinchao Zhang and Guoyuan Zhu and Mengsu Yang and Peigen Xiao",

year = "2006",

month = oct,

doi = "10.1021/np060113h",

language = "English",

volume = "69",

pages = "1500--1502",

journal = "Journal of Natural Products",

issn = "0163-3864",

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}

TY - JOUR

T1 - Cytotoxic cycloartane triterpene saponins from Actaea asiatica

AU - Gao, Jingchun

AU - Huang, Feng

AU - Zhang, Jinchao

AU - Zhu, Guoyuan

AU - Yang, Mengsu

AU - Xiao, Peigen

PY - 2006/10

Y1 - 2006/10

N2 - Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-D-xyloside (5), and 25-annydrocimigenol-β-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. © 2006 American Chemical Society and American Society of Pharmacognosy.

AB - Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-D-xyloside (5), and 25-annydrocimigenol-β-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. © 2006 American Chemical Society and American Society of Pharmacognosy.

UR - https://www.scopus.com/pages/publications/33845442302

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33845442302&origin=recordpage

U2 - 10.1021/np060113h

DO - 10.1021/np060113h

M3 - RGC 21 - Publication in refereed journal

C2 - 17067171

SN - 0163-3864

VL - 69

SP - 1500

EP - 1502

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Cytotoxic cycloartane triterpene saponins from Actaea asiatica

Abstract

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