Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis

Ze Tian; Lijia Xu; Sibao Chen; Liang Zhou; Mengsu Yang; Shilin Chen; Peigen Xiao; Erxi Wu

doi:10.1159/000102582

Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis

Ze Tian
, Lijia Xu
, Sibao Chen
, Liang Zhou
, Mengsu Yang
, Shilin Chen
, Peigen Xiao
, Erxi Wu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

20 Citations (Scopus)

Abstract

Cycloartane triterpenoid schisandrolic acid and isoschisandrolic acid were isolated from Schisandra propinqua (Wall.) Baill (Schisandraceae). Their cytotoxicity was evaluated in several cancer cell lines and primary cultured normal mouse hepatocytes. The two triterpenoids showed moderate cytotoxic activity on all tested cell lines. Fluorescence staining and cell cycle analyses were employed to elucidate the primary mechanisms of their cytotoxicity. Our results showed that two triterpenoids exerted their cytotoxic activity via G₀/G₁ arrest and subsequent apoptosis. Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds. Copyright © 2007 S. Karger AG.

Original language	English
Pages (from-to)	257-262
Journal	Chemotherapy
Volume	53
Issue number	4
DOIs	https://doi.org/10.1159/000102582
Publication status	Published - Jul 2007

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Apoptosis
Cell cycle
Isoschisandrolic acid
Poly-ADP-ribose polymerase
Schisandrolic acid

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10.1159/000102582

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@article{b47f82418eba43b7bf96609904786ea8,

title = "Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis",

abstract = "Cycloartane triterpenoid schisandrolic acid and isoschisandrolic acid were isolated from Schisandra propinqua (Wall.) Baill (Schisandraceae). Their cytotoxicity was evaluated in several cancer cell lines and primary cultured normal mouse hepatocytes. The two triterpenoids showed moderate cytotoxic activity on all tested cell lines. Fluorescence staining and cell cycle analyses were employed to elucidate the primary mechanisms of their cytotoxicity. Our results showed that two triterpenoids exerted their cytotoxic activity via G0/G1 arrest and subsequent apoptosis. Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds. Copyright {\textcopyright} 2007 S. Karger AG.",

keywords = "Apoptosis, Cell cycle, Isoschisandrolic acid, Poly-ADP-ribose polymerase, Schisandrolic acid",

author = "Ze Tian and Lijia Xu and Sibao Chen and Liang Zhou and Mengsu Yang and Shilin Chen and Peigen Xiao and Erxi Wu",

year = "2007",

month = jul,

doi = "10.1159/000102582",

language = "English",

volume = "53",

pages = "257--262",

journal = "Chemotherapy",

issn = "0009-3157",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis

AU - Tian, Ze

AU - Xu, Lijia

AU - Chen, Sibao

AU - Zhou, Liang

AU - Yang, Mengsu

AU - Chen, Shilin

AU - Xiao, Peigen

AU - Wu, Erxi

PY - 2007/7

Y1 - 2007/7

N2 - Cycloartane triterpenoid schisandrolic acid and isoschisandrolic acid were isolated from Schisandra propinqua (Wall.) Baill (Schisandraceae). Their cytotoxicity was evaluated in several cancer cell lines and primary cultured normal mouse hepatocytes. The two triterpenoids showed moderate cytotoxic activity on all tested cell lines. Fluorescence staining and cell cycle analyses were employed to elucidate the primary mechanisms of their cytotoxicity. Our results showed that two triterpenoids exerted their cytotoxic activity via G0/G1 arrest and subsequent apoptosis. Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds. Copyright © 2007 S. Karger AG.

AB - Cycloartane triterpenoid schisandrolic acid and isoschisandrolic acid were isolated from Schisandra propinqua (Wall.) Baill (Schisandraceae). Their cytotoxicity was evaluated in several cancer cell lines and primary cultured normal mouse hepatocytes. The two triterpenoids showed moderate cytotoxic activity on all tested cell lines. Fluorescence staining and cell cycle analyses were employed to elucidate the primary mechanisms of their cytotoxicity. Our results showed that two triterpenoids exerted their cytotoxic activity via G0/G1 arrest and subsequent apoptosis. Furthermore, proteolytic cleavage of poly-ADP-ribose polymerase (PARP), substrate of the caspase family, was detected and associated with apoptosis in HepG2 cells induced by the two compounds. Copyright © 2007 S. Karger AG.

KW - Apoptosis

KW - Cell cycle

KW - Isoschisandrolic acid

KW - Poly-ADP-ribose polymerase

KW - Schisandrolic acid

UR - https://www.scopus.com/pages/publications/34447532347

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-34447532347&origin=recordpage

U2 - 10.1159/000102582

DO - 10.1159/000102582

M3 - RGC 21 - Publication in refereed journal

C2 - 17496413

SN - 0009-3157

VL - 53

SP - 257

EP - 262

JO - Chemotherapy

JF - Chemotherapy

IS - 4

ER -

Cytotoxic activity of schisandrolic and isoschisandrolic acids involves induction of apoptosis

Abstract

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