Cytocompatibility, osseointegration, and bioactivity of three-dimensional porous and nanostructured network on polyetheretherketone

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Ying Zhao
  • Hoi Man Wong
  • Wenhao Wang
  • Penghui Li
  • Zushun Xu
  • Eva Y.W. Chong
  • Chun Hoi Yan
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)9264-9277
Journal / PublicationBiomaterials
Volume34
Issue number37
Online published14 Sep 2013
Publication statusPublished - Dec 2013

Abstract

Porous biomaterials with the proper three-dimensional (3D) surface network can enhance biological functionalities especially in tissue engineering, but it has been difficult to accomplish this on an important biopolymer, polyetheretherketone (PEEK), due to its inherent chemical inertness. In this study, a 3D porous and nanostructured network with bio-functional groups is produced on PEEK by sulfonation and subsequent water immersion. Two kinds of sulfonation-treated PEEK (SPEEK) samples, SPEEK-W (water immersion and rinsing after sulfonation) and SPEEK-WA (SPEEK-W with further acetone rinsing) are prepared. The surface characteristics, invitro cellular behavior, invivo osseointegration, and apatite-forming ability are systematically investigated by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, cell adhesion and cell proliferation assay, real-time RT-PCR analysis, micro-CT evaluation, push-out tests, and immersion tests. SPEEK-WA induces pre-osteoblast functions including initial cell adhesion, proliferation, and osteogenic differentiation invitro as well as substantially enhanced osseointegration and bone-implant bonding strength invivo and apatite-forming ability. Although SPEEK-W has a similar surface morphology and chemical composition as SPEEK-WA, its cytocompatibility is inferior due to residual sulfuric acid. Our results reveal that the pre-osteoblast functions, bone growth, and apatite formation on the SPEEK surfaces are affected by many factors, including positive effects introduced by the 3D porous structure and SO3H groups as well as negative ones due to the low pH environment. Surface functionalization broadens the use of PEEK in orthopedic implants. © 2013 Elsevier Ltd.

Research Area(s)

  • Bioactivity, Biocompatibility, Interface, Osseointegration, Polyetheretherketone, Surface modification

Citation Format(s)

Cytocompatibility, osseointegration, and bioactivity of three-dimensional porous and nanostructured network on polyetheretherketone. / Zhao, Ying; Wong, Hoi Man; Wang, Wenhao; Li, Penghui; Xu, Zushun; Chong, Eva Y.W.; Yan, Chun Hoi; Yeung, Kelvin W.K.; Chu, Paul K.

In: Biomaterials, Vol. 34, No. 37, 12.2013, p. 9264-9277.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review